The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation

Stuart R Gray; Graham Baker; Annemarie Wright; Claire F Fitzsimons; Nanette Mutrie; Myra A Nimmo; Scottish Physical Activity Research Collaboration (SPARColl)

doi:10.1016/j.ypmed.2008.10.013

The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation

Stuart R Gray, Graham Baker, Annemarie Wright, Claire F Fitzsimons, Nanette Mutrie, Myra A Nimmo, Scottish Physical Activity Research Collaboration (SPARColl)

Life and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

OBJECTIVES: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.

METHODS: Participants (age=49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n=24; 6 males, no change in walking) and intervention group (n=24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).

RESULTS: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P>0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P<0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.

CONCLUSION: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	Preventive Medicine
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.ypmed.2008.10.013
Publication status	Published - Jan 2009

Keywords

Adolescent
Adult
Aged
Biological Markers
Female
Humans
Insulin Resistance
Male
Middle Aged
Monitoring, Physiologic
Scotland
Systemic Inflammatory Response Syndrome
Walking
Young Adult

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10.1016/j.ypmed.2008.10.013

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title = "The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation",

abstract = "OBJECTIVES: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.METHODS: Participants (age=49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n=24; 6 males, no change in walking) and intervention group (n=24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).RESULTS: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P>0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P<0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.CONCLUSION: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.",

keywords = "Adolescent, Adult, Aged, Biological Markers, Female, Humans, Insulin Resistance, Male, Middle Aged, Monitoring, Physiologic, Scotland, Systemic Inflammatory Response Syndrome, Walking, Young Adult",

author = "Gray, {Stuart R} and Graham Baker and Annemarie Wright and Fitzsimons, {Claire F} and Nanette Mutrie and Nimmo, {Myra A} and {Scottish Physical Activity Research Collaboration (SPARColl)}",

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AU - Baker, Graham

AU - Wright, Annemarie

AU - Fitzsimons, Claire F

AU - Mutrie, Nanette

AU - Nimmo, Myra A

AU - Scottish Physical Activity Research Collaboration (SPARColl)

PY - 2009/1

Y1 - 2009/1

N2 - OBJECTIVES: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.METHODS: Participants (age=49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n=24; 6 males, no change in walking) and intervention group (n=24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).RESULTS: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P>0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P<0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.CONCLUSION: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.

AB - OBJECTIVES: The purpose of the present study was to determine whether a community-based walking intervention, using pedometers, is effective in reducing systemic inflammatory markers.METHODS: Participants (age=49(8.9)) were recruited in Glasgow, United Kingdom, from August to December 2006 and were randomly assigned to a control (n=24; 6 males, no change in walking) and intervention group (n=24; 5 males gradually increasing walking by 3000 steps/day on 5 days of the week). Blood samples were collected at baseline, and after 12 weeks, and analysed for glucose, insulin, high sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors I and II (sTNFR1 and sTNFRII).RESULTS: In the control group baseline step counts were 6356 (2953) steps/day and did not change (P>0.05) after 12 weeks, 6709 (2918) steps/day. The intervention group increased (P<0.001) step count from 6682 (3761) steps/day at baseline to 10182 (4081) steps/day at 12 weeks. Over the 12 week period there was no change in any other variables measured, in either control or intervention group.CONCLUSION: We conclude that the current community-based intervention did not affect systemic markers of inflammation or insulin sensitivity.

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KW - Adult

KW - Aged

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KW - Humans

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Monitoring, Physiologic

KW - Scotland

KW - Systemic Inflammatory Response Syndrome

KW - Walking

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U2 - 10.1016/j.ypmed.2008.10.013

DO - 10.1016/j.ypmed.2008.10.013

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SN - 0091-7435

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SP - 39

EP - 44

JO - Preventive Medicine

JF - Preventive Medicine

IS - 1

ER -

The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation

Abstract

Keywords

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