The dynamics of signal triggering in a gp130-receptor complex

R Matadeen; WC Hon; John Heath; EY Jones; S Fuller

doi:10.1016/j.str.2007.02.006

The dynamics of signal triggering in a gp130-receptor complex

R Matadeen
, WC Hon
, John Heath
, EY Jones
, S Fuller

Biosciences

Research output: Contribution to journal › Article

51 Citations (Scopus)

Abstract

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.

Original language	English
Pages (from-to)	441-448
Number of pages	8
Journal	Structure
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.str.2007.02.006
Publication status	Published - 1 Apr 2007

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10.1016/j.str.2007.02.006

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title = "The dynamics of signal triggering in a gp130-receptor complex",

abstract = "gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.",

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AU - Heath, John

AU - Jones, EY

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AB - gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.

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DO - 10.1016/j.str.2007.02.006

M3 - Article

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VL - 15

SP - 441

EP - 448

JO - Structure

JF - Structure

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The dynamics of signal triggering in a gp130-receptor complex

Abstract

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