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Abstract
Monocytes are considered to play a central role in the pathogenesis of Cryptococcus neoformans infection. Monocytes and monocyte-derived macrophages and dendritic cells are key components for the control of infection, but paradoxically they can also contribute to detrimental host responses and may even support fungal proliferation and dissemination. Simultaneously, the C. neoformans polysaccharide capsule can impair the functions of monocytes. Although monocytes are often seen as simple precursor cells, they also function as independent immune effector cells. In this review, we summarize these monocyte-specific functions during cryptococcal infection and the influence of C. neoformans on monocyte responses. We also cover the most recent findings on the functional and phenotypic heterogeneity of monocytes and discuss how new advanced technologies provide a platform to address outstanding questions in the field.
Original language | English |
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Article number | 111 |
Pages (from-to) | 1-14 |
Journal | Journal of Fungi |
Volume | 6 |
Issue number | 3 |
DOIs | |
Publication status | Published - 16 Jul 2020 |
Keywords
- Cryptococcus neoformans
- flow cytometry
- inflammatory monocytes
- mass cytometry
- monocyte subsets
- monocytes
- single-cell RNA-seq
- trained immunity
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Dive into the research topics of 'The Diverse Roles of Monocytes in Cryptococcosis'. Together they form a unique fingerprint.Projects
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Fungi on the brain: Interrogating Host-Pathogen Interactions during Fungal Meningitis
1/10/19 → 31/01/25
Project: Research Councils