Abstract
Adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties, may provide a mechanism by which insulin resistance accelerates autoimmunity in type 1 diabetes (T1D). Its actions are mediated by two receptors, adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2). In this study, we measured their distribution on human peripheral mononuclear cells by flow cytometry. ADIPOR1 is present approximately on 1% of T cells, 93% of monocytes, 47% of B cells, and 21% of NK cells (P <0.01 for difference between subsets). The distribution of ADIPOR2 was found to be similar (r= 0.992, P <0.01), and staining could be blocked in an antigen-specific manner. We were also able to confirm our finding at an RNA level by PCR using sequence-specific primers. Our data are consistent with an immunoregulatory role for adiponectin in T1D.
Original language | English |
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Pages (from-to) | 143-5 |
Number of pages | 3 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1150 |
DOIs | |
Publication status | Published - 1 Dec 2008 |
Keywords
- adiponectin
- type 1 diabetes
- insulin resistance