TY - JOUR
T1 - The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups
AU - Cook, MA
AU - Moss, Paul
AU - Briggs, David
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Killer-cell immunoglobulin-like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction-sequence-specific primers (PCR-SSP) method for typing KIRs using genomic DNA, we compared KIR frequencies in three ethnic populations drawn from UK blood donors. We found a significantly lower frequency of the inhibitory KIRs KIR2DS1 and 3DS1 in Afro-Caribbean blood donors. Despite this, there was a (non-significant) increase in the B haplotype in Afro-Caribbean and Indian Asian donors. Some donors from each group tested negative for all non-inhibitory KIRs. In addition, we describe several new KIR profiles. Analysis of linkage disequilibrium was consistent with previously published findings.
AB - Killer-cell immunoglobulin-like receptors (KIRs) can inhibit the killing activity of natural killer (NK) cells if they interact with their ligand, class I HLA. Using a modified polymerase chain reaction-sequence-specific primers (PCR-SSP) method for typing KIRs using genomic DNA, we compared KIR frequencies in three ethnic populations drawn from UK blood donors. We found a significantly lower frequency of the inhibitory KIRs KIR2DS1 and 3DS1 in Afro-Caribbean blood donors. Despite this, there was a (non-significant) increase in the B haplotype in Afro-Caribbean and Indian Asian donors. Some donors from each group tested negative for all non-inhibitory KIRs. In addition, we describe several new KIR profiles. Analysis of linkage disequilibrium was consistent with previously published findings.
UR - http://www.scopus.com/inward/record.url?scp=0038311704&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2370.2003.00394.x
DO - 10.1046/j.1365-2370.2003.00394.x
M3 - Article
C2 - 12787000
SN - 1365-2370
VL - 30
SP - 213
EP - 221
JO - European Journal of Immunogenetics
JF - European Journal of Immunogenetics
IS - 3
ER -