The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series

Daniele Borsetto; Jonathan M. Fussey; Diego Cazzador; Joel Smith; Andrea Ciorba; Stefano Pelucchi; Sara Donà; Paolo Boscolo-Rizzo; Michele Tomasoni; Davide Lombardi; Piero Nicolai; Elisabetta Zanoletti; Roberta Colangeli; Enzo Emanuelli; Max S. Osborne; Syed F. Ahsan; Margherita Tofanelli; Giancarlo Tirelli; Katherine McNamara; Leonard Liew; Katherine Harrison; Ambrogio Fassina; Samantha Sarcognato; Neil Sharma; Kanishka Rao; Paul Pracy; Paul Nankivell

doi:10.1002/hed.26032

The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series

Daniele Borsetto^*
, Jonathan M. Fussey
, Diego Cazzador
, Joel Smith
, Andrea Ciorba
, Stefano Pelucchi
, Sara Donà
, Paolo Boscolo-Rizzo
, Michele Tomasoni
, Davide Lombardi
, Piero Nicolai
, Elisabetta Zanoletti
, Roberta Colangeli
, Enzo Emanuelli
, Max S. Osborne
, Syed F. Ahsan
, Margherita Tofanelli
, Giancarlo Tirelli
, Katherine McNamara
, Leonard Liew

Katherine Harrison, Ambrogio Fassina, Samantha Sarcognato, Neil Sharma, Kanishka Rao, Paul Pracy, Paul Nankivell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively.

Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded.

Results: A total of 496 tumors were identified. In 88.9%, the final histological diagnosis was WT. In 21 cases (4.2%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology.

Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.

Original language	English
Pages (from-to)	522-529
Number of pages	8
Journal	Head and Neck
Volume	42
Issue number	3
Early online date	24 Nov 2019
DOIs	https://doi.org/10.1002/hed.26032
Publication status	Published - Mar 2020

Keywords

extracapsular dissection
facial nerve palsy
fine needle aspiration cytology
parotid
parotidectomy
Warthin's tumor

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26032

Cite this

Borsetto, D., Fussey, J. M., Cazzador, D., Smith, J., Ciorba, A., Pelucchi, S., Donà, S., Boscolo-Rizzo, P., Tomasoni, M., Lombardi, D., Nicolai, P., Zanoletti, E., Colangeli, R., Emanuelli, E., Osborne, M. S., Ahsan, S. F., Tofanelli, M., Tirelli, G., McNamara, K., ... Nankivell, P. (2020). The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series. Head and Neck, 42(3), 522-529. https://doi.org/10.1002/hed.26032

@article{8a4953421a4444a8935b30bfda58e493,

title = "The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series",

abstract = "Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively. Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded. Results: A total of 496 tumors were identified. In 88.9\%, the final histological diagnosis was WT. In 21 cases (4.2\%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology. Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.",

keywords = "extracapsular dissection, facial nerve palsy, fine needle aspiration cytology, parotid, parotidectomy, Warthin's tumor",

author = "Daniele Borsetto and Fussey, \{Jonathan M.\} and Diego Cazzador and Joel Smith and Andrea Ciorba and Stefano Pelucchi and Sara Don{\`a} and Paolo Boscolo-Rizzo and Michele Tomasoni and Davide Lombardi and Piero Nicolai and Elisabetta Zanoletti and Roberta Colangeli and Enzo Emanuelli and Osborne, \{Max S.\} and Ahsan, \{Syed F.\} and Margherita Tofanelli and Giancarlo Tirelli and Katherine McNamara and Leonard Liew and Katherine Harrison and Ambrogio Fassina and Samantha Sarcognato and Neil Sharma and Kanishka Rao and Paul Pracy and Paul Nankivell",

year = "2020",

month = mar,

doi = "10.1002/hed.26032",

language = "English",

volume = "42",

pages = "522--529",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "3",

}

Borsetto, D, Fussey, JM, Cazzador, D, Smith, J, Ciorba, A, Pelucchi, S, Donà, S, Boscolo-Rizzo, P, Tomasoni, M, Lombardi, D, Nicolai, P, Zanoletti, E, Colangeli, R, Emanuelli, E, Osborne, MS, Ahsan, SF, Tofanelli, M, Tirelli, G, McNamara, K, Liew, L, Harrison, K, Fassina, A, Sarcognato, S, Sharma, N, Rao, K, Pracy, P & Nankivell, P 2020, 'The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series', Head and Neck, vol. 42, no. 3, pp. 522-529. https://doi.org/10.1002/hed.26032

TY - JOUR

T1 - The diagnostic value of cytology in parotid Warthin's tumors

T2 - international multicenter series

AU - Borsetto, Daniele

AU - Fussey, Jonathan M.

AU - Cazzador, Diego

AU - Smith, Joel

AU - Ciorba, Andrea

AU - Pelucchi, Stefano

AU - Donà, Sara

AU - Boscolo-Rizzo, Paolo

AU - Tomasoni, Michele

AU - Lombardi, Davide

AU - Nicolai, Piero

AU - Zanoletti, Elisabetta

AU - Colangeli, Roberta

AU - Emanuelli, Enzo

AU - Osborne, Max S.

AU - Ahsan, Syed F.

AU - Tofanelli, Margherita

AU - Tirelli, Giancarlo

AU - McNamara, Katherine

AU - Liew, Leonard

AU - Harrison, Katherine

AU - Fassina, Ambrogio

AU - Sarcognato, Samantha

AU - Sharma, Neil

AU - Rao, Kanishka

AU - Pracy, Paul

AU - Nankivell, Paul

PY - 2020/3

Y1 - 2020/3

N2 - Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively. Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded. Results: A total of 496 tumors were identified. In 88.9%, the final histological diagnosis was WT. In 21 cases (4.2%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology. Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.

AB - Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively. Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded. Results: A total of 496 tumors were identified. In 88.9%, the final histological diagnosis was WT. In 21 cases (4.2%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology. Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.

KW - extracapsular dissection

KW - facial nerve palsy

KW - fine needle aspiration cytology

KW - parotid

KW - parotidectomy

KW - Warthin's tumor

UR - https://www.scopus.com/pages/publications/85075458098

U2 - 10.1002/hed.26032

DO - 10.1002/hed.26032

M3 - Article

C2 - 31762130

AN - SCOPUS:85075458098

SN - 1043-3074

VL - 42

SP - 522

EP - 529

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -

The diagnostic value of cytology in parotid Warthin's tumors: international multicenter series

Abstract

Keywords

ASJC Scopus subject areas

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