TY - JOUR
T1 - The diagnostic value of cytology in parotid Warthin's tumors
T2 - international multicenter series
AU - Borsetto, Daniele
AU - Fussey, Jonathan M.
AU - Cazzador, Diego
AU - Smith, Joel
AU - Ciorba, Andrea
AU - Pelucchi, Stefano
AU - Donà, Sara
AU - Boscolo-Rizzo, Paolo
AU - Tomasoni, Michele
AU - Lombardi, Davide
AU - Nicolai, Piero
AU - Zanoletti, Elisabetta
AU - Colangeli, Roberta
AU - Emanuelli, Enzo
AU - Osborne, Max S.
AU - Ahsan, Syed F.
AU - Tofanelli, Margherita
AU - Tirelli, Giancarlo
AU - McNamara, Katherine
AU - Liew, Leonard
AU - Harrison, Katherine
AU - Fassina, Ambrogio
AU - Sarcognato, Samantha
AU - Sharma, Neil
AU - Rao, Kanishka
AU - Pracy, Paul
AU - Nankivell, Paul
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively. Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded. Results: A total of 496 tumors were identified. In 88.9%, the final histological diagnosis was WT. In 21 cases (4.2%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology. Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.
AB - Introduction: Warthin's tumor (WT) is a common benign salivary gland neoplasm with a negligible risk of malignant transformation. However, there is a risk of malignant tumors being misdiagnosed as WT on cytology and inappropriately managed conservatively. Methods: Patients from nine centers in Italy and the United Kingdom undergoing parotid surgery for cytologically diagnosed WT were included in this multicenter retrospective series. Definitive histology was compared with preoperative cytological diagnoses. Surgical complications were recorded. Results: A total of 496 tumors were identified. In 88.9%, the final histological diagnosis was WT. In 21 cases (4.2%) a malignant neoplasm was diagnosed, which had been incorrectly labeled as WT on cytology. Conclusions: The risk of undiagnosed malignancy should be balanced against surgical risks when considering the management of WT. Although nonsurgical management remains an appropriate option, there may be a rationale for serial clinical or radiological evaluation if surgical excision is not performed.
KW - extracapsular dissection
KW - facial nerve palsy
KW - fine needle aspiration cytology
KW - parotid
KW - parotidectomy
KW - Warthin's tumor
UR - http://www.scopus.com/inward/record.url?scp=85075458098&partnerID=8YFLogxK
U2 - 10.1002/hed.26032
DO - 10.1002/hed.26032
M3 - Article
C2 - 31762130
AN - SCOPUS:85075458098
SN - 1043-3074
VL - 42
SP - 522
EP - 529
JO - Head & Neck
JF - Head & Neck
IS - 3
ER -