The Cost-effectiveness of drug treatments for primary prevention of cardiovascular disease: a modelling study

    Research output: Contribution to journalArticle

    9 Citations (Scopus)


    BACKGROUND: Efficient prevention policies need to be informed by knowledge of the cost-effectiveness of preventive treatments. This paper calculates the cost-effectiveness of aspirin, antihypertensive treatments and statins for prevention of cardiovascular disease. DESIGN: The investigation is a modelling study. METHODS: Ten-year cardiovascular risks and treatment eligibility were determined for each individual in a population of 5603 obtained from the Health Survey of England. Using published costs and evidence of effectiveness the cost-effectiveness of treating each eligible individual was determined over a 10-year time horizon. The marginal cost-effectiveness of additional antihypertensive drugs and increasing doses of statins were determined and a sensitivity analysis was carried out. RESULTS: Of the 5603 individuals 27.5% (95% confidence interval, 26.3-28.7%) were eligible for at least one treatment: the majority of these were eligible for all three. Cost per cardiovascular disease event prevented is strongly determined by pretreatment cardiovascular disease risk. In three-quarters of patients eligible for all three treatments, the lowest cost per event prevented was with aspirin and in the remainder with two-drug antihypertensive treatment. The marginal costs per event prevented were highest with the addition of a fourth antihypertensive drug and statins. These findings depend on the use of low-cost antihypertensives but are otherwise robust to a wide range of assumptions. CONCLUSIONS: Modelling the cost-effectiveness of treatments to prevent cardiovascular disease is feasible and provides valuable information. Cost-effectiveness analysis argues for more widespread use of aspirin and two-drug antihypertensive treatment and against the use of four-drug antihypertensive treatment or statins.
    Original languageEnglish
    Pages (from-to)523-528
    Number of pages6
    JournalEuropean Journal of Cardiovascular Prevention & Rehabilitation
    Issue number4
    Publication statusPublished - 1 Aug 2006


    • cost-effectiveness
    • aspirin
    • cardiovascular disease
    • statins
    • antihypertensive treatment


    Dive into the research topics of 'The Cost-effectiveness of drug treatments for primary prevention of cardiovascular disease: a modelling study'. Together they form a unique fingerprint.

    Cite this