The contribution of autophagy and LncRNAs to MYC-driven gene regulatory networks in cancers

Leila Jahangiri; Perla Pucci; Tala Ishola; Ricky M Trigg; John A Williams; Joao Pereira; Megan L Cavanagh; Suzanne D Turner; Georgios V Gkoutos; Loukia Tsaprouni

doi:10.3390/ijms22168527

The contribution of autophagy and LncRNAs to MYC-driven gene regulatory networks in cancers

Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni

Cancer and Genomic Sciences

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Abstract

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

Original language	English
Article number	8527
Number of pages	20
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	16
DOIs	https://doi.org/10.3390/ijms22168527
Publication status	Published - 8 Aug 2021

Bibliographical note

Funding Information:
Acknowledgments: G.V.G. acknowledges support from the NIHR Birmingham ECMC; NIHR Birmingham SRMRC; Nanocommons Horizon 2020-EU (731032); the NIHR Birmingham Biomedical Research Centre; and the MRC HDR UK (HDRUK/CFC/01), an initiative funded by UK Research and Innovation, Department of Health and Social Care (England), and the devolved administrations and leading medical research charities. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, the Medical Research Council, or the Department of Health.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

MYC
gene regulatory networks (GRNs)
autophagy
lncRNAs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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JahangiriL2021contribution Final published version, 1.96 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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title = "The contribution of autophagy and LncRNAs to MYC-driven gene regulatory networks in cancers",

abstract = "MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.",

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note = "Funding Information: Acknowledgments: G.V.G. acknowledges support from the NIHR Birmingham ECMC; NIHR Birmingham SRMRC; Nanocommons Horizon 2020-EU (731032); the NIHR Birmingham Biomedical Research Centre; and the MRC HDR UK (HDRUK/CFC/01), an initiative funded by UK Research and Innovation, Department of Health and Social Care (England), and the devolved administrations and leading medical research charities. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, the Medical Research Council, or the Department of Health. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Cavanagh, Megan L

AU - Turner, Suzanne D

AU - Gkoutos, Georgios V

AU - Tsaprouni, Loukia

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N2 - MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

AB - MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

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KW - lncRNAs

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The contribution of autophagy and LncRNAs to MYC-driven gene regulatory networks in cancers

Abstract

Bibliographical note

Keywords

UN SDGs

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