Projects per year
Abstract
Meiosis is a specialized cell division essential for sexual reproduction. During meiosis the chromosomes are highly organized, and correct chromosome architecture is required for faithful segregation of chromosomes at anaphase I and II. Condensin is involved in chromosome organization during meiotic and mitotic cell divisions. Three condensin subunits, AtSMC4 and the condensin I and II specific subunits AtCAP-D2 and AtCAP-D3, respectively, have been studied for their role in meiosis. This has revealed that both the condensin I and condensin II complexes are required to maintain normal structural integrity of the meiotic chromosomes during the two nuclear divisions. Their roles appear functionally distinct in that condensin I is required to maintain normal compaction of the centromeric repeats and 45S rDNA, whereas loss of condensin II was associated with extensive interchromosome connections at metaphase I. Depletion of condensin is also associated with a slight reduction in crossover formation, suggesting a role during meiotic prophase I.
Original language | English |
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Pages (from-to) | 255-68 |
Number of pages | 14 |
Journal | The Plant journal : for cell and molecular biology |
Volume | 80 |
Issue number | 2 |
Early online date | 4 Sept 2014 |
DOIs | |
Publication status | Published - 1 Oct 2014 |
Keywords
- condensin complex
- meiosis
- chromosome segregation
- recombination
- Arabidopsis thaliana
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Dive into the research topics of 'The condensin complexes play distinct roles to ensure normal chromosome morphogenesis during meiotic division in Arabidopsis'. Together they form a unique fingerprint.Projects
- 2 Finished
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ERA-CAPS 13 Delineating the crossover control networks in plants (DeCOP)
Franklin, C. & Sanchez-Moran, E.
Biotechnology & Biological Sciences Research Council
1/04/14 → 30/09/17
Project: Research Councils
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Defining the Meiotic Proteome of Higher Plants
Franklin, C., Jones, G. & Ride, J.
Biotechnology & Biological Sciences Research Council
1/05/04 → 30/06/07
Project: Research Councils