The cocrystal nicotinamide-succinic acid (2/1)

Laura Thompson, Raja Voguri, Adam Cowell, Louise Male, Maryjane Tremayne

Research output: Contribution to journalArticle

12 Citations (Scopus)


In the asymmetric unit of the crystal structure of nicotinamide-succinic acid (2/1), 2C(6)H(6)N(2)O center dot C4H6O4, there are two independent nicotinamide molecules in general positions and two half succinic acid molecules which lie about inversion centres. The structure contains acid-pyridine and amide-amide synthons with nicotinamide molecules forming ladders of alternating R (2) 2(8) and R (4) 2(8) rings linked through succinic acid to generate a corrugated hydrogen-bonded sheet. This sheet is a common supramolecular unit found in other 2:1 nicotinamide-dicarboxylic acid cocrystals, but the presence of two crystallographically distinct nicotinamides with anti and syn conformations, forming two distinct sheets within the same structure, is a novel packing feature in this type of material.
Original languageEnglish
Pages (from-to)o421-o424
JournalActa Crystallographica Section C Crystal Structure Communications
Publication statusPublished - 1 Aug 2010


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