The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health

Richard D Horniblow; Gladys O Latunde-Dada; Stephen E Harding; Melanie Schneider; Manroy Sahni; Ahsan Bhatti; Christian Ludwig; Ian T Norton; Tariq H Iqbal; Chris Tselepis

doi:10.1002/mnfr.201500882

The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health

Richard D Horniblow, Gladys O Latunde-Dada, Stephen E Harding, Melanie Schneider, Manroy Sahni, Ahsan Bhatti, Christian Ludwig, Ian T Norton, Tariq H Iqbal, Chris Tselepis

Research output: Contribution to journal › Article › peer-review

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Abstract

SCOPE: Scope: Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore the aims of this study were to screen a panel of alginates to identify a therapeutic that can chelate this pool of iron and thus be beneficial for intestinal health.

SCOPE: Methods and results: Using several in vitro intestinal models it is evident that only one alginate (Manucol LD) of the panel tested was able to inhibit intracellular iron accumulation as assessed by iron mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations and by measuring iron flux across a Caco-2 monolayer. Additionally, Manucol LD suppressed iron absorption in mice which was associated with increased faecal iron levels indicating iron chelation within the gastrointestinal tract. Furthermore, the bioactivity of Manucol LD was found to be highly dependent on both its molecular weight and its unique compositional sequence.

SCOPE: Conclusion: Manucol LD could be useful for the chelation of this detrimental pool of unabsorbed iron and it could be fortified in foods to enhance intestinal health. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Molecular Nutrition & Food Research
Early online date	2 May 2016
DOIs	https://doi.org/10.1002/mnfr.201500882
Publication status	E-pub ahead of print - 2 May 2016

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This is the peer reviewed version of the following article: Horniblow, Richard D., et al. "The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health." Molecular nutrition & food research (2016)., which has been published in final form at http://dx.doi.org/10.1002/mnfr.201500882. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Archiving allowed under Wiley/RCUK policy - checked 2nd June 2016
Accepted author manuscript, 827 KBLicence: None: All rights reserved

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Horniblow, R. D., Latunde-Dada, G. O., Harding, S. E., Schneider, M., Sahni, M., Bhatti, A., Ludwig, C., Norton, I. T., Iqbal, T. H., & Tselepis, C. (2016). The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health. Molecular Nutrition & Food Research. Advance online publication. https://doi.org/10.1002/mnfr.201500882

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title = "The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health",

abstract = "SCOPE: Scope: Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore the aims of this study were to screen a panel of alginates to identify a therapeutic that can chelate this pool of iron and thus be beneficial for intestinal health.SCOPE: Methods and results: Using several in vitro intestinal models it is evident that only one alginate (Manucol LD) of the panel tested was able to inhibit intracellular iron accumulation as assessed by iron mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations and by measuring iron flux across a Caco-2 monolayer. Additionally, Manucol LD suppressed iron absorption in mice which was associated with increased faecal iron levels indicating iron chelation within the gastrointestinal tract. Furthermore, the bioactivity of Manucol LD was found to be highly dependent on both its molecular weight and its unique compositional sequence.SCOPE: Conclusion: Manucol LD could be useful for the chelation of this detrimental pool of unabsorbed iron and it could be fortified in foods to enhance intestinal health. This article is protected by copyright. All rights reserved.",

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AU - Sahni, Manroy

AU - Bhatti, Ahsan

AU - Ludwig, Christian

AU - Norton, Ian T

AU - Iqbal, Tariq H

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N2 - SCOPE: Scope: Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore the aims of this study were to screen a panel of alginates to identify a therapeutic that can chelate this pool of iron and thus be beneficial for intestinal health.SCOPE: Methods and results: Using several in vitro intestinal models it is evident that only one alginate (Manucol LD) of the panel tested was able to inhibit intracellular iron accumulation as assessed by iron mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations and by measuring iron flux across a Caco-2 monolayer. Additionally, Manucol LD suppressed iron absorption in mice which was associated with increased faecal iron levels indicating iron chelation within the gastrointestinal tract. Furthermore, the bioactivity of Manucol LD was found to be highly dependent on both its molecular weight and its unique compositional sequence.SCOPE: Conclusion: Manucol LD could be useful for the chelation of this detrimental pool of unabsorbed iron and it could be fortified in foods to enhance intestinal health. This article is protected by copyright. All rights reserved.

AB - SCOPE: Scope: Iron is an essential nutrient. However, in animal models, excess unabsorbed dietary iron residing within the colonic lumen has been shown to exacerbate inflammatory bowel disease and intestinal cancer. Therefore the aims of this study were to screen a panel of alginates to identify a therapeutic that can chelate this pool of iron and thus be beneficial for intestinal health.SCOPE: Methods and results: Using several in vitro intestinal models it is evident that only one alginate (Manucol LD) of the panel tested was able to inhibit intracellular iron accumulation as assessed by iron mediated ferritin induction, transferrin receptor expression, intracellular (59) Fe concentrations and by measuring iron flux across a Caco-2 monolayer. Additionally, Manucol LD suppressed iron absorption in mice which was associated with increased faecal iron levels indicating iron chelation within the gastrointestinal tract. Furthermore, the bioactivity of Manucol LD was found to be highly dependent on both its molecular weight and its unique compositional sequence.SCOPE: Conclusion: Manucol LD could be useful for the chelation of this detrimental pool of unabsorbed iron and it could be fortified in foods to enhance intestinal health. This article is protected by copyright. All rights reserved.

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SN - 1613-4125

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

ER -

The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health

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