The Born in Guangzhou Cohort Study (BIGCS)

Qiu Xiu, Jin-Hua Lu, Jian-Rong He, King-bong Hubert Lam, Song-Ying Shen, Yong Guo, Ya-Shu Kuang, Ming-Yang Yuan, Lan Qiu, Nian-Nian Chen, Min-Shan Lu , Wei-Dong Li, Yan-Fei Xing , Suzanne Bartington, Feng-Juan Zhou, Kar Cheng, Hui-Min Xia

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The Born in Guangzhou Cohort Study (BIGCS) is a large-scale prospective
observational study investigating the role of social, biological and environmental
influences on pregnancy and child health and development in an urban setting in
southern China. Pregnant women who reside in Guangzhou and who attend
Guangzhou Women and Children's Medical Center (GWCMC) for antenatal care in
early pregnancy (less than 20 weeks' gestation) are eligible for inclusion. Study
recruitment commenced in February 2012, with an overall participation rate of 76.3%. Study recruitment will continue until December 2018 to achieve the target sample size of 30 000 mother-child pairs. At 30 April 2016, a total of 75 422 questionnaires have been collected, while 14 696 live births have occurred with planned follow-up of cohort children until age 18 years. During the same period a total of 1 053 000 biological samples have been collected from participants, including maternal, paternal and infant blood, cord blood, placenta, umbilical cord, and maternal and infant stool samples. The dataset has been enhanced by record linkage to routine health and administrative
records. We plan future record linkage to school enrolment and national examination records.
Original languageEnglish
Pages (from-to)337–346
JournalEuropean Journal of Epidemiology
Issue number4
Early online date20 Mar 2017
Publication statusPublished - Apr 2017


  • Record Linkage
  • Design
  • Cohort Study
  • Child
  • Pregnancy


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