The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation

Elton A. M. P. Dudink; Bob  Weijs; Samantha Tull; Justin G. L. M. Luermans; Larissa Fabritz; Wei Ling Chua; Michiel  Rienstra; Isabelle C Van Gelder; Ulrich Schotten; Paulus Kirchhof; Harry J G M Crijns

The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation

Elton A. M. P. Dudink, Bob Weijs, Samantha Tull, Justin G. L. M. Luermans, Larissa Fabritz, Wei Ling Chua, Michiel Rienstra, Isabelle C Van Gelder, Ulrich Schotten, Paulus Kirchhof, Harry J G M Crijns

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Abstract

Background: Blood biomarkers related to AF could be useful to detect silent AF and to develop stratified strategies for AF prevention. Previous studies identified markers that predict incident AF. However, it is difficult to differentiate whether biomarkers relate to underlying cardiovascular diseases, are generated by the atria in response to an AF episode, or both. We therefore measured a panel of blood biomarkers in patients without overt CVD with and without AF to investigate the association between biomarkers and atrial fibrillation (AF) in patients without overt cardiovascular disease (CVD).
Methods: Blood samples – drawn remote from an AF episode – of 60 patients with AF but without overt forms of CVD (idiopathic AF; iAF) were compared to 120 matched patients with sinus rhythm only. A novel antibody-based method for quantification of blood biomarkers (OlinkProseek Multiplex Cardiovascular) was used to compare 92 biomarkers between the two groups.
Results: N-terminal pro-B-type natriuretic peptide (NT-proBNP), Cathepsin L1, Endothelial cell-specific molecule 1, Cancer Antigen-125 (CA-125), Heat shock 27kDa protein, Galanin peptides, Proteinase-activated receptor 1, Stem cell factor, and CD40-ligand were all higher in iAF patients than in SR controls. Both NT-proBNP (OR1.55(1.07–2.25);p=0.022) and CA-125 (OR1.68(1.07-2.64);p=0.026) were independently associated with iAF.
Conclusions: This exploratory study, investigating over 90 cardiovascular blood biomarkers in patients without known CVD, identified one established biomarker for paroxysmal AF,

Original language	English
Number of pages	7
Journal	Journal of Atrial Fibrillation
Volume	11
Issue number	4
Publication status	Published - 4 Mar 2019

Keywords

Biomarkers
Atrial Fibrillation
Chronic Coronary Disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.jafib.com/published.php?type=full&id=2058Licence: Creative Commons: Attribution (CC BY)

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Dudink, E. A. M. P., Weijs, B., Tull, S., Luermans, J. G. L. M., Fabritz, L., Chua, W. L., Rienstra, M., Van Gelder, I. C., Schotten, U., Kirchhof, P., & Crijns, H. J. G. M. (2019). The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation. Journal of Atrial Fibrillation, 11(4). http://www.jafib.com/published.php?type=full&id=2058

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title = "The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation",

abstract = "Background: Blood biomarkers related to AF could be useful to detect silent AF and to develop stratified strategies for AF prevention. Previous studies identified markers that predict incident AF. However, it is difficult to differentiate whether biomarkers relate to underlying cardiovascular diseases, are generated by the atria in response to an AF episode, or both. We therefore measured a panel of blood biomarkers in patients without overt CVD with and without AF to investigate the association between biomarkers and atrial fibrillation (AF) in patients without overt cardiovascular disease (CVD).Methods: Blood samples – drawn remote from an AF episode – of 60 patients with AF but without overt forms of CVD (idiopathic AF; iAF) were compared to 120 matched patients with sinus rhythm only. A novel antibody-based method for quantification of blood biomarkers (OlinkProseek Multiplex Cardiovascular) was used to compare 92 biomarkers between the two groups.Results: N-terminal pro-B-type natriuretic peptide (NT-proBNP), Cathepsin L1, Endothelial cell-specific molecule 1, Cancer Antigen-125 (CA-125), Heat shock 27kDa protein, Galanin peptides, Proteinase-activated receptor 1, Stem cell factor, and CD40-ligand were all higher in iAF patients than in SR controls. Both NT-proBNP (OR1.55(1.07–2.25);p=0.022) and CA-125 (OR1.68(1.07-2.64);p=0.026) were independently associated with iAF.Conclusions: This exploratory study, investigating over 90 cardiovascular blood biomarkers in patients without known CVD, identified one established biomarker for paroxysmal AF,",

keywords = "Biomarkers, Atrial Fibrillation, Chronic Coronary Disease",

author = "Dudink, {Elton A. M. P.} and Bob Weijs and Samantha Tull and Luermans, {Justin G. L. M.} and Larissa Fabritz and Chua, {Wei Ling} and Michiel Rienstra and {Van Gelder}, {Isabelle C} and Ulrich Schotten and Paulus Kirchhof and Crijns, {Harry J G M}",

year = "2019",

month = mar,

day = "4",

language = "English",

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journal = "Journal of Atrial Fibrillation",

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TY - JOUR

T1 - The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation

AU - Dudink, Elton A. M. P.

AU - Weijs, Bob

AU - Tull, Samantha

AU - Luermans, Justin G. L. M.

AU - Fabritz, Larissa

AU - Chua, Wei Ling

AU - Rienstra, Michiel

AU - Van Gelder, Isabelle C

AU - Schotten, Ulrich

AU - Kirchhof, Paulus

AU - Crijns, Harry J G M

PY - 2019/3/4

Y1 - 2019/3/4

N2 - Background: Blood biomarkers related to AF could be useful to detect silent AF and to develop stratified strategies for AF prevention. Previous studies identified markers that predict incident AF. However, it is difficult to differentiate whether biomarkers relate to underlying cardiovascular diseases, are generated by the atria in response to an AF episode, or both. We therefore measured a panel of blood biomarkers in patients without overt CVD with and without AF to investigate the association between biomarkers and atrial fibrillation (AF) in patients without overt cardiovascular disease (CVD).Methods: Blood samples – drawn remote from an AF episode – of 60 patients with AF but without overt forms of CVD (idiopathic AF; iAF) were compared to 120 matched patients with sinus rhythm only. A novel antibody-based method for quantification of blood biomarkers (OlinkProseek Multiplex Cardiovascular) was used to compare 92 biomarkers between the two groups.Results: N-terminal pro-B-type natriuretic peptide (NT-proBNP), Cathepsin L1, Endothelial cell-specific molecule 1, Cancer Antigen-125 (CA-125), Heat shock 27kDa protein, Galanin peptides, Proteinase-activated receptor 1, Stem cell factor, and CD40-ligand were all higher in iAF patients than in SR controls. Both NT-proBNP (OR1.55(1.07–2.25);p=0.022) and CA-125 (OR1.68(1.07-2.64);p=0.026) were independently associated with iAF.Conclusions: This exploratory study, investigating over 90 cardiovascular blood biomarkers in patients without known CVD, identified one established biomarker for paroxysmal AF,

AB - Background: Blood biomarkers related to AF could be useful to detect silent AF and to develop stratified strategies for AF prevention. Previous studies identified markers that predict incident AF. However, it is difficult to differentiate whether biomarkers relate to underlying cardiovascular diseases, are generated by the atria in response to an AF episode, or both. We therefore measured a panel of blood biomarkers in patients without overt CVD with and without AF to investigate the association between biomarkers and atrial fibrillation (AF) in patients without overt cardiovascular disease (CVD).Methods: Blood samples – drawn remote from an AF episode – of 60 patients with AF but without overt forms of CVD (idiopathic AF; iAF) were compared to 120 matched patients with sinus rhythm only. A novel antibody-based method for quantification of blood biomarkers (OlinkProseek Multiplex Cardiovascular) was used to compare 92 biomarkers between the two groups.Results: N-terminal pro-B-type natriuretic peptide (NT-proBNP), Cathepsin L1, Endothelial cell-specific molecule 1, Cancer Antigen-125 (CA-125), Heat shock 27kDa protein, Galanin peptides, Proteinase-activated receptor 1, Stem cell factor, and CD40-ligand were all higher in iAF patients than in SR controls. Both NT-proBNP (OR1.55(1.07–2.25);p=0.022) and CA-125 (OR1.68(1.07-2.64);p=0.026) were independently associated with iAF.Conclusions: This exploratory study, investigating over 90 cardiovascular blood biomarkers in patients without known CVD, identified one established biomarker for paroxysmal AF,

KW - Biomarkers

KW - Atrial Fibrillation

KW - Chronic Coronary Disease

M3 - Article

SN - 1941-6911

VL - 11

JO - Journal of Atrial Fibrillation

JF - Journal of Atrial Fibrillation

IS - 4

ER -

The biomarkers NT-proBNP and CA-125 are elevated in patients with idiopathic atrial fibrillation

Abstract

Keywords

UN SDGs

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