The biology of immunoglobulin free light chains and kidney injury.

Kolitha Basnayake, Stephanie Stringer, CA Hutchison, Paul Cockwell

Research output: Contribution to journalArticle

66 Citations (Scopus)


Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.Kidney International advance online publication, 13 April 2011; doi:10.1038/ki.2011.94.
Original languageEnglish
JournalKidney International
Publication statusPublished - 13 Apr 2011


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