The biology of immunoglobulin free light chains and kidney injury.

Kolitha Basnayake; Stephanie Stringer; CA Hutchison; Paul Cockwell

doi:10.1038/ki.2011.94

The biology of immunoglobulin free light chains and kidney injury.

Kolitha Basnayake, Stephanie Stringer, CA Hutchison, Paul Cockwell

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Abstract

Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.Kidney International advance online publication, 13 April 2011; doi:10.1038/ki.2011.94.

Original language	English
Journal	Kidney International
DOIs	https://doi.org/10.1038/ki.2011.94
Publication status	Published - 13 Apr 2011

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10.1038/ki.2011.94

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title = "The biology of immunoglobulin free light chains and kidney injury.",

abstract = "Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.Kidney International advance online publication, 13 April 2011; doi:10.1038/ki.2011.94.",

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AB - Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.Kidney International advance online publication, 13 April 2011; doi:10.1038/ki.2011.94.

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The biology of immunoglobulin free light chains and kidney injury.

Abstract

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