The biology of Gram-positive sortase enzymes

Gavin K Paterson, Timothy J Mitchell

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)


Surface proteins of Gram-positive pathogens play various key roles in pathogenicity. Therefore, these proteins are of great interest in terms of understanding the infection process and have potential as targets for therapy. A major mechanism for the surface display of proteins by Gram-positive bacteria is sortase-mediated covalent attachment to the cell wall. The importance of sortase enzymes in the virulence of several pathogens is now becoming apparent, as are some of the more detailed workings of the enzyme and anchoring pathway. These recent advances are discussed.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalTrends in Microbiology
Issue number2
Publication statusPublished - Feb 2004


  • Amino Acid Motifs
  • Aminoacyltransferases
  • Bacterial Proteins
  • Cell Wall
  • Cysteine Endopeptidases
  • Gram-Positive Bacteria
  • Membrane Proteins
  • Models, Molecular
  • Protein Binding
  • Protein Structure, Tertiary
  • Substrate Specificity
  • Virulence


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