The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

C Nadebaum; V Anderson; F Vajda; D Reutens; S Barton; Amanda Wood

doi:10.1017/S1355617710001359

The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

C Nadebaum, V Anderson, F Vajda, D Reutens, S Barton, Amanda Wood

Psychology

Research output: Contribution to journal › Article

68 Citations (Scopus)

Abstract

Prenatal exposure to sodium valproate (VPA) and polytherapy has been linked with increased risk of birth defects and cognitive impairment in young children. We evaluated the cognitive impact of prenatal exposure to VPA and polytherapy in school-aged children. Fifty-seven children exposed to VPA (a = 23), polytherapy with VPA (n = 15), or polytherapy without VPA (a = 19) were assessed using the Wechsler Intelligence Scale for Children Fourth Edition. Information on maternal epilepsy, pregnancy, and medical history was obtained prospectively through the Australian Pregnancy Register for Women with Epilepsy and Allied Disorders. All groups had elevated frequencies of Extremely Low (

Original language	English
Pages (from-to)	133-142
Number of pages	10
Journal	Journal of the International Neuropsychological Society
Volume	17
Issue number	1
DOIs	https://doi.org/10.1017/S1355617710001359
Publication status	Published - 1 Jan 2011

Keywords

Prenatal exposure delayed effects
Intelligence
Epilepsy
Child development
Anticonvulsants
Pregnancy

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10.1017/S1355617710001359

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The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in School-Aged Children Exposed to Sodium Valproate and Polytherapy

Abstract

Keywords

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