The association between inadequate sleep and accelerated brain ageing

Jivesh Ramduny; Matteo Bastiani; Robin Huedepohl; Stamatios N. Sotiropoulos; Magdalena Chechlacz

doi:10.1016/j.neurobiolaging.2022.02.005

The association between inadequate sleep and accelerated brain ageing

Jivesh Ramduny, Matteo Bastiani, Robin Huedepohl, Stamatios N. Sotiropoulos, Magdalena Chechlacz

Psychology

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Abstract

Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported findings are highly inconsistent. By contrast to previous research independently characterizing patterns of either GM or WM changes, we used here linked independent component analysis (FLICA) to examine covariation in GM and WM in a group of older adults (n=50). Next, we employed a novel technique to estimate the brain age delta (difference between chronological and brain age assessed using neuroimaging data) and study its associations with sleep quality and sleep fragmentation, hypothesizing that inadequate sleep accelerates brain ageing. FLICA revealed a number of multimodal components, associated with age, sleep quality and sleep fragmentation. Subsequently, we show significant associations between brain age delta and inadequate sleep, suggesting two years deviation above the chronological age. Our findings indicate sensitivity of multimodal approaches and brain age delta in detecting link between inadequate sleep and accelerated brain ageing.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Neurobiology of Aging
Volume	114
Early online date	19 Feb 2022
DOIs	https://doi.org/10.1016/j.neurobiolaging.2022.02.005
Publication status	Published - Jun 2022

Bibliographical note

Funding Information:
We warmly thank the volunteers from the School of Psychology panel and the Birmingham 1000 Elders group for participation in this study. This work was supported by the Birmingham-Nottingham Strategic Collaboration Fund (BNSCF336 to SNS and MC) and by a Wellcome Trust Institutional Strategic Support Fund critical data award (204846/Z/16/Z to MC). SS was also supported by the Wellcome Trust (217266/Z/19/Z) and by an ERC Consolidator Grant (101000969). MC was also supported by a BRIDGE (Birmingham-Illinois Partnership for Discovery, Engagement and Education) Fellowship.

Keywords

Ageing
Brain age
Gray matter
Magnetic resonance imaging
Sleep
White matter

ASJC Scopus subject areas

Neuroscience(all)
Ageing
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

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Cite this

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title = "The association between inadequate sleep and accelerated brain ageing",

abstract = "Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported findings are highly inconsistent. By contrast to previous research independently characterizing patterns of either GM or WM changes, we used here linked independent component analysis (FLICA) to examine covariation in GM and WM in a group of older adults (n=50). Next, we employed a novel technique to estimate the brain age delta (difference between chronological and brain age assessed using neuroimaging data) and study its associations with sleep quality and sleep fragmentation, hypothesizing that inadequate sleep accelerates brain ageing. FLICA revealed a number of multimodal components, associated with age, sleep quality and sleep fragmentation. Subsequently, we show significant associations between brain age delta and inadequate sleep, suggesting two years deviation above the chronological age. Our findings indicate sensitivity of multimodal approaches and brain age delta in detecting link between inadequate sleep and accelerated brain ageing.",

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The association between inadequate sleep and accelerated brain ageing

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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