The Assessment of T-Cell Apoptosis in Synovial Fluid

Karim Raza, Dagmar Scheel-Toellner, Janet Lord, AN Akbar, Christopher Buckley, Michael Salmon

Research output: Chapter in Book/Report/Conference proceedingChapter


T-cell apoptosis is central to the resolution of chronic inflammation. Inhibition of this process of programmed cell death contributes to disease persistence in conditions such as rheumatoid arthritis. An understanding of T-cell apoptosis and its regulation is clearly important for understanding the pathophysiology of inflammatory disease. This chapter describes a number of apoptosis assays that can be used to measure T-cell apoptosis in synovial fluid. The choice of assay depends, in part, on the phase of apoptosis under investigation and this review puts this into context by introducing these phases and their regulation.
Original languageEnglish
Title of host publicationMethods in Molecular Medicine: Arthritis Research
EditorsAndrew P. Cope
ISBN (Electronic)9781597454025
ISBN (Print)9781588299185
Publication statusPublished - 1 Jul 2006

Publication series

NameMethods in Molecular Medicine
ISSN (Print)1543-1894


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