The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease

Michael Gleeson; Nicolette C Bishop; David J Stensel; Martin R Lindley; Sarabjit S Mastana; Myra A Nimmo

doi:10.1038/nri3041

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease

Michael Gleeson^*, Nicolette C Bishop, David J Stensel, Martin R Lindley, Sarabjit S Mastana, Myra A Nimmo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

990 Citations (Scopus)

Abstract

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

Original language	English
Pages (from-to)	607-615
Number of pages	9
Journal	Nature Reviews Immunology
Volume	11
Issue number	9
Early online date	5 Aug 2011
DOIs	https://doi.org/10.1038/nri3041
Publication status	Published - Sept 2011

Keywords

Adipokines
Animals
Athletes
Cytokines
Epinephrine
Exercise
Humans
Hydrocortisone
Immune System
Inflammation Mediators
Lipids
Mice
Obesity
Toll-Like Receptors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nri3041

Cite this

@article{8715717f8f9e4e70b64140614ca8d22b,

title = "The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease",

abstract = "Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.",

keywords = "Adipokines, Animals, Athletes, Cytokines, Epinephrine, Exercise, Humans, Hydrocortisone, Immune System, Inflammation Mediators, Lipids, Mice, Obesity, Toll-Like Receptors",

author = "Michael Gleeson and Bishop, {Nicolette C} and Stensel, {David J} and Lindley, {Martin R} and Mastana, {Sarabjit S} and Nimmo, {Myra A}",

year = "2011",

month = sep,

doi = "10.1038/nri3041",

language = "English",

volume = "11",

pages = "607--615",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - The anti-inflammatory effects of exercise

T2 - mechanisms and implications for the prevention and treatment of disease

AU - Gleeson, Michael

AU - Bishop, Nicolette C

AU - Stensel, David J

AU - Lindley, Martin R

AU - Mastana, Sarabjit S

AU - Nimmo, Myra A

PY - 2011/9

Y1 - 2011/9

N2 - Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

AB - Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

KW - Adipokines

KW - Animals

KW - Athletes

KW - Cytokines

KW - Epinephrine

KW - Exercise

KW - Humans

KW - Hydrocortisone

KW - Immune System

KW - Inflammation Mediators

KW - Lipids

KW - Mice

KW - Obesity

KW - Toll-Like Receptors

U2 - 10.1038/nri3041

DO - 10.1038/nri3041

M3 - Article

C2 - 21818123

SN - 1474-1733

VL - 11

SP - 607

EP - 615

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 9

ER -

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this