The activation of the CGRP receptor

James Barwell, Mark Wheatley, Alex C Conner, Bruck Taddese, Shabana Vohra, Christopher A Reynolds, David R Poyner

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Original languageEnglish
Pages (from-to)180-4
Number of pages5
JournalBiochemical Society Transactions
Issue number1
Publication statusPublished - 1 Feb 2013


  • Crystallography, X-Ray
  • Protein Binding
  • Receptors, Calcitonin Gene-Related Peptide


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