Abstract
Lindane (5 x 10(-5) M) causes a progressive and marked rise in MEPP frequency at the frog neuromuscular junction. Concentrations over a range of 5 x 10(-6) M to 5 x 10(-4) M were tested. The results suggest that it has two actions in promoting this effect. Its major effect is probably to cause an increase in Ca2+-permeability and a rise in Ca2+ entry. Its second, smaller effect, which persists in the absence of extracellular Ca2+, is probably also because of a rise in [Ca2+]i. The ways in which these effects might be produced and the significance of these findings for explaining the known pharmacological actions of lindane are discussed.
Original language | English |
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Pages (from-to) | 179-82 |
Number of pages | 4 |
Journal | Naunyn-Schmiedeberg's Archives of Pharmacology |
Volume | 308 |
Issue number | 2 |
Publication status | Published - Aug 1979 |
Keywords
- Animals
- Anura
- Calcium
- In Vitro Techniques
- Lindane
- Motor Endplate
- Neuromuscular Junction
- Neurotransmitter Agents
- Rana temporaria
- Time Factors