Abstract
RATIONALE: Whilst the FDA-approved anorectic, lorcaserin and various 5-hydroxytryptamine (5-HT)6 receptor antagonists reduce feeding, a direct assessment of their impact upon feeding behaviour is less clear. We therefore examined the action of lorcaserin and the clinical-stage developmental candidate 5-HT6 receptor antagonist, SB-742457, upon microstructural analysis of licking behaviour. Such analysis provides a rich source of information about the mechanisms controlling food intake.
OBJECTIVES: The objective of the present study was to gain insight into the influence upon feeding behaviour of the 5-HT2C receptor agonist, lorcaserin and the developmental 5-HT6 receptor antagonist, SB-742457.
METHODS: The impact of lorcaserin and SB-742457 upon licking behaviour of non-deprived rats for a glucose solution was assessed using microstructural analysis.
RESULTS: Lorcaserin (0.1-3.0 mg/kg) displayed a dose-dependent ability to reduce glucose consumption via reduction in the number of bouts of licking. A similar action was evident with SB-742457, but only at the lowest dose tested (3.0 mg/kg).
CONCLUSIONS: The behavioural actions of both lorcaserin and SB-742457 demonstrate they directly promote satiety.
| Original language | English |
|---|---|
| Pages (from-to) | 417-424 |
| Journal | Psychopharmacology |
| Volume | 233 |
| Issue number | 3 |
| Early online date | 28 Oct 2015 |
| DOIs | |
| Publication status | Published - Feb 2016 |
Keywords
- Lorcaserin
- 5-HT2C receptor
- 5-HT6 receptor
- Obesity
- Feeding behaviour
- Microstructural analysis
