TFF2 inhibits apoptosis in breast and colorectal cancer cell lines

L-S Siu, PD Abel, Hanna Romanska, M Baus-Loncar, T Kayademir, GWH Stamp, El-Nasir Lalani

Research output: Contribution to journalArticle

24 Citations (Scopus)


We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2-) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.
Original languageEnglish
Pages (from-to)855-863
Number of pages9
Publication statusPublished - 1 May 2004


Dive into the research topics of 'TFF2 inhibits apoptosis in breast and colorectal cancer cell lines'. Together they form a unique fingerprint.

Cite this