Tetraspanin protein contributions to cancer

Hong-Xing Wang; Qinglin Li; Chandan Sharma; Konstantin Knoblich; Martin E Hemler

doi:10.1042/BST0390547

Tetraspanin protein contributions to cancer

Hong-Xing Wang, Qinglin Li, Chandan Sharma, Konstantin Knoblich, Martin E Hemler

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

54 Citations (Scopus)

Abstract

Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion, migration, metastasis, signalling and drug sensitivity. Tetraspanin CD9 has suppressor functions in multiple tumour cell types. Major CD9 partner proteins, such as EWI-2 and EWI-F, may modulate these tumour-suppressor functions. Tetraspanin Tspan12 mutations are linked to a human disease called familial exudative vitreoretinopathy. In addition, as a regulator of the metalloprotease ADAM10 (a disintegrin and metalloprotease 10) maturation and function, Tspan12 probably contributes to the pro-tumorigenic functions of ADAM10.

Original language	English
Pages (from-to)	547-52
Number of pages	6
Journal	Biochemical Society Transactions
Volume	39
Issue number	2
DOIs	https://doi.org/10.1042/BST0390547
Publication status	Published - Apr 2011

Keywords

ADAM Proteins
Amyloid Precursor Protein Secretases
Animals
Antigens, CD
Antigens, CD151
Antigens, CD9
Humans
Integrins
Membrane Glycoproteins
Membrane Proteins
Neoplasms
Protein Binding
Tetraspanins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/BST0390547

Cite this

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title = "Tetraspanin protein contributions to cancer",

abstract = "Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion, migration, metastasis, signalling and drug sensitivity. Tetraspanin CD9 has suppressor functions in multiple tumour cell types. Major CD9 partner proteins, such as EWI-2 and EWI-F, may modulate these tumour-suppressor functions. Tetraspanin Tspan12 mutations are linked to a human disease called familial exudative vitreoretinopathy. In addition, as a regulator of the metalloprotease ADAM10 (a disintegrin and metalloprotease 10) maturation and function, Tspan12 probably contributes to the pro-tumorigenic functions of ADAM10.",

keywords = "ADAM Proteins, Amyloid Precursor Protein Secretases, Animals, Antigens, CD, Antigens, CD151, Antigens, CD9, Humans, Integrins, Membrane Glycoproteins, Membrane Proteins, Neoplasms, Protein Binding, Tetraspanins",

author = "Hong-Xing Wang and Qinglin Li and Chandan Sharma and Konstantin Knoblich and Hemler, {Martin E}",

year = "2011",

month = apr,

doi = "10.1042/BST0390547",

language = "English",

volume = "39",

pages = "547--52",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press",

number = "2",

}

TY - JOUR

T1 - Tetraspanin protein contributions to cancer

AU - Wang, Hong-Xing

AU - Li, Qinglin

AU - Sharma, Chandan

AU - Knoblich, Konstantin

AU - Hemler, Martin E

PY - 2011/4

Y1 - 2011/4

N2 - Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion, migration, metastasis, signalling and drug sensitivity. Tetraspanin CD9 has suppressor functions in multiple tumour cell types. Major CD9 partner proteins, such as EWI-2 and EWI-F, may modulate these tumour-suppressor functions. Tetraspanin Tspan12 mutations are linked to a human disease called familial exudative vitreoretinopathy. In addition, as a regulator of the metalloprotease ADAM10 (a disintegrin and metalloprotease 10) maturation and function, Tspan12 probably contributes to the pro-tumorigenic functions of ADAM10.

AB - Among the 33 human tetraspanin proteins, CD151, CD9 and Tspan12 play particularly important roles in cancer. Tetraspanin CD151, in partnership with integrins α6β1 and α6β4, modulates tumour cell growth, invasion, migration, metastasis, signalling and drug sensitivity. Tetraspanin CD9 has suppressor functions in multiple tumour cell types. Major CD9 partner proteins, such as EWI-2 and EWI-F, may modulate these tumour-suppressor functions. Tetraspanin Tspan12 mutations are linked to a human disease called familial exudative vitreoretinopathy. In addition, as a regulator of the metalloprotease ADAM10 (a disintegrin and metalloprotease 10) maturation and function, Tspan12 probably contributes to the pro-tumorigenic functions of ADAM10.

KW - ADAM Proteins

KW - Amyloid Precursor Protein Secretases

KW - Animals

KW - Antigens, CD

KW - Antigens, CD151

KW - Antigens, CD9

KW - Humans

KW - Integrins

KW - Membrane Glycoproteins

KW - Membrane Proteins

KW - Neoplasms

KW - Protein Binding

KW - Tetraspanins

U2 - 10.1042/BST0390547

DO - 10.1042/BST0390547

M3 - Review article

C2 - 21428937

SN - 0300-5127

VL - 39

SP - 547

EP - 552

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 2

ER -

Tetraspanin protein contributions to cancer

Abstract

Keywords

UN SDGs

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