Research output per year
Research output per year
Rachael Bailey, Sara Priego Moreno, Agnieszka Gambus
Research output: Contribution to journal › Article › peer-review
To ensure duplication of the entire genome, eukaryotic DNA replication initiates from thousands of replication origins. The replication forks move through the chromatin until they encounter forks from neighbouring origins. During replication fork termination forks converge, the replisomes disassemble and topoisomerase II resolves the daughter DNA molecules. If not resolved efficiently, terminating forks result in genomic instability through the formation of pathogenic structures. Our recent findings shed light onto the mechanism of replisome disassembly upon replication fork termination. We have shown that termination-specific polyubiquitylation of the replicative helicase component - Mcm7, leads to dissolution of the active helicase in a process dependent on the p97/VCP/Cdc48 segregase. The inhibition of terminating helicase disassembly resulted in a replication termination defect. In this extended view we present hypothetical models of replication fork termination and discuss remaining and emerging questions in the DNA replication termination field.
Original language | English |
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Pages (from-to) | 187-196 |
Journal | Nucleus (Austin) |
Volume | 6 |
Issue number | 3 |
Early online date | 2 Apr 2015 |
DOIs | |
Publication status | E-pub ahead of print - 2 Apr 2015 |
Research output: Contribution to journal › Article › peer-review
Gambus, A. (Recipient), 1 Mar 2013
Prize: Fellowship awarded competitively