TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

A M Jones; A D Beggs; L Carvajal-Carmona; S Farrington; A Tenesa; M Walker; K Howarth; S Ballereau; S V Hodgson; A Zauber; M Bertagnolli; R Midgley; H Campbell; D Kerr; M G Dunlop; I P M Tomlinson

doi:10.1136/gut.2011.239772

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

A M Jones, A D Beggs, L Carvajal-Carmona, S Farrington, A Tenesa, M Walker, K Howarth, S Ballereau, S V Hodgson, A Zauber, M Bertagnolli, R Midgley, H Campbell, D Kerr, M G Dunlop, I P M Tomlinson

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.

Original language	English
Pages (from-to)	248-54
Number of pages	7
Journal	Gut
Volume	61
Issue number	2
DOIs	https://doi.org/10.1136/gut.2011.239772
Publication status	Published - 2012

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10.1136/gut.2011.239772

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Jones, A. M., Beggs, A. D., Carvajal-Carmona, L., Farrington, S., Tenesa, A., Walker, M., Howarth, K., Ballereau, S., Hodgson, S. V., Zauber, A., Bertagnolli, M., Midgley, R., Campbell, H., Kerr, D., Dunlop, M. G., & Tomlinson, I. P. M. (2012). TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut, 61(2), 248-54. https://doi.org/10.1136/gut.2011.239772

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abstract = "Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.",

author = "Jones, {A M} and Beggs, {A D} and L Carvajal-Carmona and S Farrington and A Tenesa and M Walker and K Howarth and S Ballereau and Hodgson, {S V} and A Zauber and M Bertagnolli and R Midgley and H Campbell and D Kerr and Dunlop, {M G} and Tomlinson, {I P M}",

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doi = "10.1136/gut.2011.239772",

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Jones, AM, Beggs, AD, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, SV, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG & Tomlinson, IPM 2012, 'TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres', Gut, vol. 61, no. 2, pp. 248-54. https://doi.org/10.1136/gut.2011.239772

TY - JOUR

T1 - TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

AU - Jones, A M

AU - Beggs, A D

AU - Carvajal-Carmona, L

AU - Farrington, S

AU - Tenesa, A

AU - Walker, M

AU - Howarth, K

AU - Ballereau, S

AU - Hodgson, S V

AU - Zauber, A

AU - Bertagnolli, M

AU - Midgley, R

AU - Campbell, H

AU - Kerr, D

AU - Dunlop, M G

AU - Tomlinson, I P M

PY - 2012

Y1 - 2012

N2 - Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.

AB - Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.

U2 - 10.1136/gut.2011.239772

DO - 10.1136/gut.2011.239772

M3 - Article

C2 - 21708826

SN - 0017-5749

VL - 61

SP - 248

EP - 254

JO - Gut

JF - Gut

IS - 2

ER -

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

Abstract

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