Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis

Patricia A Berry, Simon W Jones, Flavia M Cicuttini, Anita E Wluka, Rose A Maciewicz

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

The association of obesity with both hand and knee osteoarthritis (OA) is suggestive of a link between dysfunctional metabolism and joint integrity. Given the role of adipokines in mediating bone and cartilage homeostasis, we undertook this study to examine the relationship between adipokines and bone and cartilage biomarkers in a population of subjects with OA, and to determine whether adipokine levels predicted 2-year cartilage integrity.
Original languageEnglish
Pages (from-to)700-7
Number of pages8
JournalArthritis & Rheumatism
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Obesity
  • Bone and Bones
  • Osteocalcin
  • Humans
  • Cartilage, Articular
  • Aged
  • Predictive Value of Tests
  • Resistin
  • Procollagen
  • Longitudinal Studies
  • Osteoarthritis, Knee
  • Leptin
  • Peptide Fragments
  • Risk Factors
  • Adiponectin
  • Middle Aged
  • Time Factors
  • Adipokines
  • Biological Markers
  • Female
  • Male

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