Telomere erosion: a new link between HLA DR4 and rheumatoid arthritis?

Michael Salmon, AN Akbar

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

Previous models used to explain the association between HLA DR4 and rheumatoid arthritis (RA) focused on the presentation of 'arthritogenic' peptides. These failed because of the diversity of HLA molecules that are associated with the disease. Patients with RA have accelerated erosion of telomeres in peripheral T cells. Recent research shows that this might be a function of HLA DR4 expression and is common to all blood cells. This offers a new perspective on the mechanism of HLA disease associations and also a link to T-cell homeostasis, which is known to be important in RA.

Original language	English
Pages (from-to)	339-341
Number of pages	3
Journal	Trends in Immunology
Volume	25
Issue number	7
DOIs	https://doi.org/10.1016/j.it.2004.05.002
Publication status	Published - 1 Jul 2004

Access to Document

10.1016/j.it.2004.05.002

Cite this

@article{bb14b19b38084f43a594959290c607ed,

title = "Telomere erosion: a new link between HLA DR4 and rheumatoid arthritis?",

abstract = "Previous models used to explain the association between HLA DR4 and rheumatoid arthritis (RA) focused on the presentation of 'arthritogenic' peptides. These failed because of the diversity of HLA molecules that are associated with the disease. Patients with RA have accelerated erosion of telomeres in peripheral T cells. Recent research shows that this might be a function of HLA DR4 expression and is common to all blood cells. This offers a new perspective on the mechanism of HLA disease associations and also a link to T-cell homeostasis, which is known to be important in RA.",

author = "Michael Salmon and AN Akbar",

year = "2004",

month = jul,

day = "1",

doi = "10.1016/j.it.2004.05.002",

language = "English",

volume = "25",

pages = "339--341",

journal = "Trends in Immunology",

issn = "1471-4981",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Telomere erosion: a new link between HLA DR4 and rheumatoid arthritis?

AU - Salmon, Michael

AU - Akbar, AN

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Previous models used to explain the association between HLA DR4 and rheumatoid arthritis (RA) focused on the presentation of 'arthritogenic' peptides. These failed because of the diversity of HLA molecules that are associated with the disease. Patients with RA have accelerated erosion of telomeres in peripheral T cells. Recent research shows that this might be a function of HLA DR4 expression and is common to all blood cells. This offers a new perspective on the mechanism of HLA disease associations and also a link to T-cell homeostasis, which is known to be important in RA.

AB - Previous models used to explain the association between HLA DR4 and rheumatoid arthritis (RA) focused on the presentation of 'arthritogenic' peptides. These failed because of the diversity of HLA molecules that are associated with the disease. Patients with RA have accelerated erosion of telomeres in peripheral T cells. Recent research shows that this might be a function of HLA DR4 expression and is common to all blood cells. This offers a new perspective on the mechanism of HLA disease associations and also a link to T-cell homeostasis, which is known to be important in RA.

UR - http://www.scopus.com/inward/record.url?scp=2942652784&partnerID=8YFLogxK

U2 - 10.1016/j.it.2004.05.002

DO - 10.1016/j.it.2004.05.002

M3 - Article

C2 - 15207499

SN - 1471-4981

VL - 25

SP - 339

EP - 341

JO - Trends in Immunology

JF - Trends in Immunology

IS - 7

ER -