TDP-43 gene analysis in frontotemporal lobar degeneration

S Rollinson, JS Snowden, D Neary, Karen Morrison, DMA Mann, SM Pickering-Brown

    Research output: Contribution to journalArticle

    37 Citations (Scopus)


    It has recently been established that the ubiquitinated neuronal inclusions and neurites observed in frontotemporal lobar degeneration (FTLD) contain the TAR DNA-binding protein, TDP-43. It is not uncommon for genetic variation of genes that encode proteins that accumulate in neurodegenerative conditions to increase risk for disease. We therefore examined whether variation of the TDP-43 locus was associated with an increased risk of disease in the Manchester FTLD cohort. We found no evidence of TDP-43 variation increasing risk for FTLD in this cohort. These data suggest that TDP-43 accumulation is a consequence of the disease process underlying FTLD.
    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalNeuroscience Letters
    Publication statusPublished - 23 May 2007


    • TDP-43
    • FTLD
    • PGRN
    • genetic association
    • frontotemporal lobar degeneration


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