Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models

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• Finished

  Human cellular platforms for studying the regulation and therapeutic application of autophagy

  Sarkar, S. (Principal Investigator)

  The Wellcome Trust

  1/07/16 → 31/12/18

  Project: Research

  • Autophagy 100%
  • Autophagy Dysfunction 44%
  • Induced Pluripotent Stem Cells (iPSCs) 42%
  • Nicotinamide Adenine Dinucleotide (NAD+) 40%
  • Cytotoxicity 40%

• WT ISSF 15/16 Identifying the autophagy regulatory kinome in the human system

  Sarkar, S. (Principal Investigator)

  Wellcome Trust

  1/05/16 → 31/10/16

  Project: Research

  • Autophagy 100%
  • Nicotinamide Adenine Dinucleotide (NAD+) 100%
  • Nicotinamide Adenine Dinucleotide 100%
  • Cell Death 66%
  • Autophagy Dysfunction 55%