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Abstract
AIM: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow.
MATERIALS & METHODS: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues.
RESULTS: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle.
CONCLUSION: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.
Original language | English |
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Pages (from-to) | 2726-2740 |
Number of pages | 14 |
Journal | Nanomedicine |
Volume | 12 |
Issue number | 22 |
Early online date | 29 Sept 2017 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- blood flow
- gold nanoparticles
- imaging
- luminescence
- metal probes
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Dive into the research topics of 'Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow'. Together they form a unique fingerprint.Projects
- 1 Finished
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Luminescent nanoparticles as trackers for imaging of flows and sensing phenomena in microchannels
Engineering & Physical Science Research Council
18/05/09 → 17/01/13
Project: Research Councils