TY - JOUR
T1 - Systems analysis of plant functional, transcriptional, physical interaction, and metabolic networks
AU - Bassel, G.W.
AU - De Smet, I.
AU - Gaudinier, A.
AU - Brady, S.M.
AU - Hennig, L.
AU - Rhee, S.Y.
N1 - Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Physiological responses, developmental programs, and cellular functions rely on complex networks of interactions at different levels and scales. Systems biology brings together high-throughput biochemical, genetic, and molecular approaches to generate omics data that can be analyzed and used in mathematical and computational models toward uncovering these networks on a global scale. Various approaches, including transcriptomics, proteomics, interactomics, and metabolomics, have been employed to obtain these data on the cellular, tissue, organ, and whole-plant level. We summarize progress on gene regulatory, cofunction, protein interaction, and metabolic networks. We also illustrate the main approaches that have been used to obtain these networks, with specific examples from Arabidopsis thaliana, and describe the pros and cons of each approach.
AB - Physiological responses, developmental programs, and cellular functions rely on complex networks of interactions at different levels and scales. Systems biology brings together high-throughput biochemical, genetic, and molecular approaches to generate omics data that can be analyzed and used in mathematical and computational models toward uncovering these networks on a global scale. Various approaches, including transcriptomics, proteomics, interactomics, and metabolomics, have been employed to obtain these data on the cellular, tissue, organ, and whole-plant level. We summarize progress on gene regulatory, cofunction, protein interaction, and metabolic networks. We also illustrate the main approaches that have been used to obtain these networks, with specific examples from Arabidopsis thaliana, and describe the pros and cons of each approach.
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-84870724279&md5=758b928580bbacce07096ea1b1cca639
U2 - 10.1105/tpc.112.100776
DO - 10.1105/tpc.112.100776
M3 - Article
AN - SCOPUS:84870724279
SN - 1040-4651
VL - 24
SP - 3859
EP - 3875
JO - The Plant Cell
JF - The Plant Cell
IS - 10
ER -