Systematic review: genetic associations for prognostic factors of urinary bladder cancer

Nadezda Lipunova; Anke Wesselius; KK Cheng; Frederik-Jan  van Schooten; Jean-Baptiste Cazier; Rik Bryan; Maurice Zeegers

doi:10.1177/1179299X19897255

Systematic review: genetic associations for prognostic factors of urinary bladder cancer

Nadezda Lipunova, Anke Wesselius, KK Cheng, Frederik-Jan van Schooten, Jean-Baptiste Cazier, Rik Bryan, Maurice Zeegers

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Abstract

Introduction: Many germline associations have been reported for urinary bladder cancer (UBC) outcomes and prognostic characteristics. It is unclear whether there are overlapping genetic patterns for various prognostic endpoints. We aimed to review contemporary literature on genetic associations with UBC prognostic outcomes and to identify potential overlap in reported genes.

Methods: EMBASE, MEDLINE, and PubMed databases were queried for relevant articles in English language without date restrictions. The initial search identified 1346 articles. After exclusions, 112 studies have been summarized. Cumulatively, 316 single-nucleotide polymorphisms (SNPs) were reported across prognostic outcomes (recurrence, progression, death) and characteristics (tumor stage, grade, size, age, risk group). There were considerable differences between studied outcomes in the context of genetic associations. The most commonly reported SNPs were located in OGG1, TP53, and MDM2. For outcomes with the highest number of reported associations (ie, recurrence and death), functional enrichment annotation yields different terms, potentially indicating separate biological mechanisms.

Conclusions: Our study suggests that all UBC prognostic outcomes may have different biological origins with limited overlap. Further validation of these observations is essential to target a phenotype that could best predict patient outcome and advance current management practices.

Original language	English
Article number	1179299X19897255
Pages (from-to)	1-9
Number of pages	9
Journal	Biomarkers in Cancer
Volume	11
Early online date	30 Dec 2019
DOIs	https://doi.org/10.1177/1179299X19897255
Publication status	E-pub ahead of print - 30 Dec 2019

Keywords

Urinary bladder cancer
Review
Prognosis
Characteristics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Final published version, 775 KBLicence: Creative Commons: Attribution (CC BY)

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2 Article

Genome-wide meta-analysis identifies novel genes associated with recurrence and progression in non-muscle-invasive bladder cancer
Galesloot, T. E., Grotenhuis, A. J., Kolev, D., Aben, K. K., Bryan, R. T., Catto, J. W. F., Cheng, K. K., Conroy, S., Dyrskjøt, L., Fleshner, N. E., James, N. D., Lamy, P., Lindskrog, S. V., Malats, N., Mengual, L., Verhaegh, G., Zeegers, M. P., Kiemeney, L. A. L. M. & Vermeulen, S. H., Feb 2022, In: European Urology Oncology. 5, 1, p. 70-83
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Genome-wide association study for tumour stage, grade, size, and age at diagnosis of non-muscle-invasive bladder cancer
Lipunova, N., Wesselius, A., Cheng, K., van Schooten, F-J., Bryan, R., Cazier, J-B., Galesloot, T., Kiemeney, L. A. & Zeegers, M., Jul 2019, In: European Urology Oncology. 2, 4, p. 381–389 9 p.
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1 Finished

Bladder Cancer Prognosis Programme
Bryan, R.
NIHR
1/05/10 → 31/07/13
Project: Other Government Departments

Cite this

@article{5a0cae2951244d929e7da38a051e5799,

title = "Systematic review: genetic associations for prognostic factors of urinary bladder cancer",

abstract = "Introduction: Many germline associations have been reported for urinary bladder cancer (UBC) outcomes and prognostic characteristics. It is unclear whether there are overlapping genetic patterns for various prognostic endpoints. We aimed to review contemporary literature on genetic associations with UBC prognostic outcomes and to identify potential overlap in reported genes.Methods: EMBASE, MEDLINE, and PubMed databases were queried for relevant articles in English language without date restrictions. The initial search identified 1346 articles. After exclusions, 112 studies have been summarized. Cumulatively, 316 single-nucleotide polymorphisms (SNPs) were reported across prognostic outcomes (recurrence, progression, death) and characteristics (tumor stage, grade, size, age, risk group). There were considerable differences between studied outcomes in the context of genetic associations. The most commonly reported SNPs were located in OGG1, TP53, and MDM2. For outcomes with the highest number of reported associations (ie, recurrence and death), functional enrichment annotation yields different terms, potentially indicating separate biological mechanisms.Conclusions: Our study suggests that all UBC prognostic outcomes may have different biological origins with limited overlap. Further validation of these observations is essential to target a phenotype that could best predict patient outcome and advance current management practices.",

keywords = "Urinary bladder cancer, Review, Prognosis, Characteristics",

author = "Nadezda Lipunova and Anke Wesselius and KK Cheng and {van Schooten}, Frederik-Jan and Jean-Baptiste Cazier and Rik Bryan and Maurice Zeegers",

year = "2019",

month = dec,

day = "30",

doi = "10.1177/1179299X19897255",

language = "English",

volume = "11",

pages = "1--9",

journal = "Biomarkers in Cancer",

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T2 - genetic associations for prognostic factors of urinary bladder cancer

AU - Lipunova, Nadezda

AU - Wesselius, Anke

AU - Cheng, KK

AU - van Schooten, Frederik-Jan

AU - Cazier, Jean-Baptiste

AU - Bryan, Rik

AU - Zeegers, Maurice

PY - 2019/12/30

Y1 - 2019/12/30

N2 - Introduction: Many germline associations have been reported for urinary bladder cancer (UBC) outcomes and prognostic characteristics. It is unclear whether there are overlapping genetic patterns for various prognostic endpoints. We aimed to review contemporary literature on genetic associations with UBC prognostic outcomes and to identify potential overlap in reported genes.Methods: EMBASE, MEDLINE, and PubMed databases were queried for relevant articles in English language without date restrictions. The initial search identified 1346 articles. After exclusions, 112 studies have been summarized. Cumulatively, 316 single-nucleotide polymorphisms (SNPs) were reported across prognostic outcomes (recurrence, progression, death) and characteristics (tumor stage, grade, size, age, risk group). There were considerable differences between studied outcomes in the context of genetic associations. The most commonly reported SNPs were located in OGG1, TP53, and MDM2. For outcomes with the highest number of reported associations (ie, recurrence and death), functional enrichment annotation yields different terms, potentially indicating separate biological mechanisms.Conclusions: Our study suggests that all UBC prognostic outcomes may have different biological origins with limited overlap. Further validation of these observations is essential to target a phenotype that could best predict patient outcome and advance current management practices.

AB - Introduction: Many germline associations have been reported for urinary bladder cancer (UBC) outcomes and prognostic characteristics. It is unclear whether there are overlapping genetic patterns for various prognostic endpoints. We aimed to review contemporary literature on genetic associations with UBC prognostic outcomes and to identify potential overlap in reported genes.Methods: EMBASE, MEDLINE, and PubMed databases were queried for relevant articles in English language without date restrictions. The initial search identified 1346 articles. After exclusions, 112 studies have been summarized. Cumulatively, 316 single-nucleotide polymorphisms (SNPs) were reported across prognostic outcomes (recurrence, progression, death) and characteristics (tumor stage, grade, size, age, risk group). There were considerable differences between studied outcomes in the context of genetic associations. The most commonly reported SNPs were located in OGG1, TP53, and MDM2. For outcomes with the highest number of reported associations (ie, recurrence and death), functional enrichment annotation yields different terms, potentially indicating separate biological mechanisms.Conclusions: Our study suggests that all UBC prognostic outcomes may have different biological origins with limited overlap. Further validation of these observations is essential to target a phenotype that could best predict patient outcome and advance current management practices.

KW - Urinary bladder cancer

KW - Review

KW - Prognosis

KW - Characteristics

U2 - 10.1177/1179299X19897255

DO - 10.1177/1179299X19897255

M3 - Article

SN - 1179-299X

VL - 11

SP - 1

EP - 9

JO - Biomarkers in Cancer

JF - Biomarkers in Cancer

M1 - 1179299X19897255

ER -

Systematic review: genetic associations for prognostic factors of urinary bladder cancer

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Research output

Genome-wide meta-analysis identifies novel genes associated with recurrence and progression in non-muscle-invasive bladder cancer

Genome-wide association study for tumour stage, grade, size, and age at diagnosis of non-muscle-invasive bladder cancer

Projects

Bladder Cancer Prognosis Programme

Cite this