Systematic integration of experimental data and models in systems biology

Peter Li; Joseph O Dada; Daniel Jameson; Irena Spasic; Neil Swainston; Kathleen Carroll; Warwick Dunn; Farid Khan; Naglis Malys; Hanan L Messiha; Evangelos Simeonidis; Dieter Weichart; Catherine Winder; Jill Wishart; David S Broomhead; Carole A Goble; Simon J Gaskell; Douglas B Kell; Hans V Westerhoff; Pedro Mendes; Norman W Paton

doi:10.1186/1471-2105-11-582

Systematic integration of experimental data and models in systems biology

Peter Li
, Joseph O Dada
, Daniel Jameson
, Irena Spasic
, Neil Swainston
, Kathleen Carroll
, Warwick Dunn
, Farid Khan
, Naglis Malys
, Hanan L Messiha
, Evangelos Simeonidis
, Dieter Weichart
, Catherine Winder
, Jill Wishart
, David S Broomhead
, Carole A Goble
, Simon J Gaskell
, Douglas B Kell
, Hans V Westerhoff
, Pedro Mendes

Norman W Paton

Biosciences

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

193 Downloads (Pure)

Abstract

The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction of a model in order to define its components and their biochemical reactions, and corresponding parameters. Automating the assembly and use of systems biology models is dependent upon data integration processes involving the interoperation of data and analytical resources.

Original language	English
Article number	582
Journal	BMC Bioinformatics
Volume	11
DOIs	https://doi.org/10.1186/1471-2105-11-582
Publication status	Published - 29 Nov 2010

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Li_et_al_Systematic_Integration_Experimental_Data_BMC_Bioinformatics_2010
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Li, P., Dada, J. O., Jameson, D., Spasic, I., Swainston, N., Carroll, K., Dunn, W., Khan, F., Malys, N., Messiha, H. L., Simeonidis, E., Weichart, D., Winder, C., Wishart, J., Broomhead, D. S., Goble, C. A., Gaskell, S. J., Kell, D. B., Westerhoff, H. V., ... Paton, N. W. (2010). Systematic integration of experimental data and models in systems biology. BMC Bioinformatics, 11, Article 582. https://doi.org/10.1186/1471-2105-11-582

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title = "Systematic integration of experimental data and models in systems biology",

abstract = "The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction of a model in order to define its components and their biochemical reactions, and corresponding parameters. Automating the assembly and use of systems biology models is dependent upon data integration processes involving the interoperation of data and analytical resources.",

author = "Peter Li and Dada, \{Joseph O\} and Daniel Jameson and Irena Spasic and Neil Swainston and Kathleen Carroll and Warwick Dunn and Farid Khan and Naglis Malys and Messiha, \{Hanan L\} and Evangelos Simeonidis and Dieter Weichart and Catherine Winder and Jill Wishart and Broomhead, \{David S\} and Goble, \{Carole A\} and Gaskell, \{Simon J\} and Kell, \{Douglas B\} and Westerhoff, \{Hans V\} and Pedro Mendes and Paton, \{Norman W\}",

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month = nov,

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Li, P, Dada, JO, Jameson, D, Spasic, I, Swainston, N, Carroll, K, Dunn, W, Khan, F, Malys, N, Messiha, HL, Simeonidis, E, Weichart, D, Winder, C, Wishart, J, Broomhead, DS, Goble, CA, Gaskell, SJ, Kell, DB, Westerhoff, HV, Mendes, P & Paton, NW 2010, 'Systematic integration of experimental data and models in systems biology', BMC Bioinformatics, vol. 11, 582. https://doi.org/10.1186/1471-2105-11-582

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AU - Li, Peter

AU - Dada, Joseph O

AU - Jameson, Daniel

AU - Spasic, Irena

AU - Swainston, Neil

AU - Carroll, Kathleen

AU - Dunn, Warwick

AU - Khan, Farid

AU - Malys, Naglis

AU - Messiha, Hanan L

AU - Simeonidis, Evangelos

AU - Weichart, Dieter

AU - Winder, Catherine

AU - Wishart, Jill

AU - Broomhead, David S

AU - Goble, Carole A

AU - Gaskell, Simon J

AU - Kell, Douglas B

AU - Westerhoff, Hans V

AU - Mendes, Pedro

AU - Paton, Norman W

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AB - The behaviour of biological systems can be deduced from their mathematical models. However, multiple sources of data in diverse forms are required in the construction of a model in order to define its components and their biochemical reactions, and corresponding parameters. Automating the assembly and use of systems biology models is dependent upon data integration processes involving the interoperation of data and analytical resources.

U2 - 10.1186/1471-2105-11-582

DO - 10.1186/1471-2105-11-582

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VL - 11

JO - BMC Bioinformatics

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Systematic integration of experimental data and models in systems biology

Abstract

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