TY - JOUR
T1 - Synthesis of mannopyranose disccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis
AU - Pathak, AK
AU - Pathak, V
AU - Riordan, JM
AU - Gurcha, Sudagar
AU - Besra, Gurdyal
AU - [No Value], [No Value]
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of alpha-(1--> 2)- and alpha-(1 --> 6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyl-transferases in Mycobacterium tuberculosis. (C) 2003 Elsevier Ltd. All rights reserved.
AB - Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of alpha-(1--> 2)- and alpha-(1 --> 6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyl-transferases in Mycobacterium tuberculosis. (C) 2003 Elsevier Ltd. All rights reserved.
KW - disaccharide
KW - photoaffinity probe
KW - mannosyltransferases
KW - mycobacterium tuberculosis
KW - marmose
UR - http://www.scopus.com/inward/record.url?scp=0842287574&partnerID=8YFLogxK
U2 - 10.1016/j.carres.2003.10.031
DO - 10.1016/j.carres.2003.10.031
M3 - Article
C2 - 15013406
VL - 339
SP - 683
EP - 691
JO - Carbohydrate Research
JF - Carbohydrate Research
ER -