Synthesis of mannopyranose disccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis

AK Pathak, V Pathak, JM Riordan, Sudagar Gurcha, Gurdyal Besra, [No Value] [No Value]

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of alpha-(1--> 2)- and alpha-(1 --> 6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyl-transferases in Mycobacterium tuberculosis. (C) 2003 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)683-691
Number of pages9
JournalCarbohydrate Research
Volume339
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • disaccharide
  • photoaffinity probe
  • mannosyltransferases
  • mycobacterium tuberculosis
  • marmose

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