Synthesis of Macrocyclic, Potential Protease Inhibitors using a Generic Scaffold

Keyphrases

• Protease Inhibitors 100%
• Potential Inhibitors 100%
• Aspartic Acid 50%
• Hydrolytic 50%
• Proteinase 50%
• Group by 50%
• Lysine 50%
• Benzoxazole 50%
• Macrocyclic Peptides 50%
• Pd-catalyzed Cross-coupling 50%
• Polypeptide Chain 50%
• Peptide Structure 50%
• Organozinc Reagents 50%
• Macrocyclization 50%
• Enzyme Class 50%
• Molecular Modeling 50%
• Enzyme-inhibitor Complex 50%
• Target Enzyme 50%
• Phenylalanine 50%
• Amino Acid Derivatives 50%
• Chymotrypsin 50%
• Bis-amino Acids 50%
• Compound 25 50%
• Linking Groups 50%
• Macrocycles 50%
• Open Chain 50%
• Enzymatic Steps 50%

Chemistry

• NMR Spectroscopy 100%
• Aspartic Acid 100%
• Amino Acid Derivative 100%
• hydrolytic 100%
• Phenylalanine 100%
• Macrocycle 100%
• macrocyclization 100%
• Enzyme Inhibitor 100%
• Molecular Model 100%
• Lysine 100%
• Macrocylic Compound 100%
• Benzoxazole 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Lysine 100%
• Proteinase 100%
• Aspartic Acid 100%
• Proteinase Inhibitor 100%
• Macrocyclic Compound 100%
• Enzyme Inhibitor 100%
• HATU 100%
• Amino Acid Derivative 100%
• Phenylalanine 100%
• Benzoxazole Derivative 100%
• Chymotrypsin 100%