Synthesis of 3,4-disubstituted piperidines by ene cyclisation of 4-aza-1,7-dienes

Stephen Walker, James Williams, Alexander Russell, John Snaith

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ene cyclisation of a variety of 4-aza-1,7-dienes affords 3,4-disubstituted piperidines. In particular, cyclisation of diesters 14 and 20 catalysed by MeAlCl2 gives the corresponding trans 3,4-disubstituted piperidines with diastereomeric ratios of > 200:1. (c) 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)6611-6615
Number of pages5
JournalTetrahedron Letters
Volume46
Issue number39
DOIs
Publication statusPublished - 26 Sep 2005

Keywords

  • cyclisation
  • piperidine
  • ene

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