Abstract
Lithium amides react with vinylferrocene in the presence of TMEDA to provide the corresponding (2-aminoethyl)ferrocenes in good to excellent yields. A range of secondary amines can be employed in this amidolithiation reaction, with cyclic derivatives affording particularly good yields of the 2-aminoethyl-substituted ferrocene product. This operationally simple procedure provides one of the most straightforward routes to this class of mono-substituted ferrocene. (c) 2006 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 761-767 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 63 |
Issue number | 3 |
DOIs | |
Publication status | Published - 15 Jan 2007 |
Keywords
- vinylferrocene
- lithium amides
- regioselective additions
- amidolithiation