Synthesis of (2-aminoethyl) ferrocenes from the reaction of lithium amides with vinylferrocene

Kevin Joly, Renate Gleixner, Simon Simpkins, DM Coe, Liam Cox

Research output: Contribution to journalArticle

9 Citations (Scopus)


Lithium amides react with vinylferrocene in the presence of TMEDA to provide the corresponding (2-aminoethyl)ferrocenes in good to excellent yields. A range of secondary amines can be employed in this amidolithiation reaction, with cyclic derivatives affording particularly good yields of the 2-aminoethyl-substituted ferrocene product. This operationally simple procedure provides one of the most straightforward routes to this class of mono-substituted ferrocene. (c) 2006 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)761-767
Number of pages7
Issue number3
Publication statusPublished - 15 Jan 2007


  • vinylferrocene
  • lithium amides
  • regioselective additions
  • amidolithiation


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