Projects per year
Abstract
A series of nitrobenzyl phosphoramide mustards and their analogs was designed and synthesized to explore their structure-activity relationships as substrates of nitroreductases from Escherichia coli and trypanosomes and as potential antiproliferative and antiparasitic agents. The position of the nitro group on the phenyl ring was important with the 4-nitrobenzyl phosphoramide mustard (1) offering the best combination of enzyme activity and antiproliferative effect against both mammalian and trypanosomatid cells. A preference was observed for halogen substitutions ortho to benzyl phosphoramide mustard but distinct differences were found in their SAR of substituted 4-nitrobenzyl phosphoramide mustards in E. coli nitroreductase-expressing cells and in trypanosomatids expressing endogenous nitroreductases. (C) 2011 Elsevier Ltd. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 3986-3991 |
Number of pages | 6 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 13 |
Early online date | 7 May 2011 |
DOIs | |
Publication status | Published - 1 Jul 2011 |
Keywords
- Nitroreductase
- Leishmania
- Trypanosoma
- Phosphoramide mustard
- Antiproliferative
- Prodrug
Fingerprint
Dive into the research topics of 'Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Prodrug Activation Gene Therapy for Cancer: Optimising Enzymes, Vectors and Immune Responses
Searle, P. (Principal Investigator), James, N. (Co-Investigator), Mautner, V. (Co-Investigator), Palmer, D. (Co-Investigator), Porfiri, E. (Co-Investigator) & Young, L. (Co-Investigator)
1/12/06 → 31/10/09
Project: Research