Synthesis and Self-Assembly of Amphiphilic Chiral Poly(amino acid) Star Polymers

Jared Skey, Helen Willcock, Mieke Lammens, Filip Du Prez, Rachel K. O'Reilly

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Reversible addition−fragmentation chain transfer (RAFT) polymerization techniques were utilized to polymerize N-acryloyl-l-phenylalanine methyl ester (l-Phe-OMe) and tetrahydropyranyl acrylate to afford amphiphilic star polymers (with 4 and 6 arms). These copolymer stars have a chiral hydrophobic core domain and can undergo further solution self-assembly to form well-defined nanostructures, which have been characterized using DLS, TEM, and cryo-TEM analysis. The characterization and properties of these novel chiral assemblies and their potential in racemic resolution are reported.
Original languageEnglish
Pages (from-to)5949-5955
Issue number14
Publication statusPublished - 1 Jul 2010


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