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Abstract
An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKTcell proliferation and elicit T-helper cytokines, IL-4 and IFN gamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related alpha-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison. (C) 2009 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 3386-3388 |
Number of pages | 3 |
Journal | Bioorganic & Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 13 |
DOIs | |
Publication status | Published - 1 Jul 2009 |
Keywords
- iNKT cell stimulation
- Glycolipids
- Alpha-galactosyl ceramides
- CD1d
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Dive into the research topics of 'Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH'. Together they form a unique fingerprint.Projects
- 1 Finished
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Modulation of Immune Responses by aGalCer Analogues Through Differential Activation of CD1d-restricted NKT Cells
Besra, D. (Principal Investigator) & Lammas, T. (Co-Investigator)
1/06/05 → 30/11/09
Project: Research Councils