Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase - a key enzyme in M. tuberculosis cell wall biosynthesis

S Cren; Sudagar Gurcha; AJ Blake; Gurdyal Besra; Neil R Thomas

doi:10.1039/b411554f

Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase - a key enzyme in M. tuberculosis cell wall biosynthesis

S Cren, Sudagar Gurcha, AJ Blake, Gurdyal Besra, Neil R Thomas

Biosciences

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Abstract

Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.

Original language	English
Pages (from-to)	2418-2420
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	2
DOIs	https://doi.org/10.1039/b411554f
Publication status	Published - 1 Jan 2004

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10.1039/b411554f

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abstract = "Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.",

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AU - Thomas, Neil R

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AB - Two iminosugars have been designed and synthesized as potential inhibitors of UDP-Galf transferase, an enzyme involved in Mycobacterium tuberculosis cell wall biosynthesis. The design is based on a proposed model of the transition state for the transferase reaction. One of the two racemic compounds is the first reported inhibitor of the target enzyme from M. smegmatis.

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Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase - a key enzyme in M. tuberculosis cell wall biosynthesis

Abstract

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