Synchrotron X-ray diffraction and scanning electron microscopy to understand enamel affected by metabolic disorder mucopolysaccharidosis

Malik Arshman Khan, Owen Addison, Alison James, Christian J. Hendriksz, Maisoon Al-jawad

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
199 Downloads (Pure)

Abstract

Mucopolysaccharidosis (MPS) is an inherited metabolic disorder that can affect the tooth structure leading to defects. Synchrotron x-ray diffraction being a state of the art technique has been used to determine the enamel crystallite orientation in deciduous enamel affected by Mucopolysaccharidosis Type I and Mucopolysaccharidosis Type IVA and comparing these with that of healthy deciduous enamel. Using this technique it was observed that there is a loss of texture in deciduous enamel affected by Mucopolysaccharidosis Type I and Mucopolysaccharidosis Type IVA when compared to the healthy deciduous enamel. Generally it was observed that the incisal surface of the deciduous teeth possessed a higher texture or preferred orientation of enamel crystallites and on progression towards the cervical region there was a decrease in the texture or preferred orientation of enamel crystallites. Scanning electron microscopy showed that the presence of a poorly calcified layer between the enamel and dentine at the enamel-dentine junction (EDJ) in MPS affected samples was likely to be responsible for rendering the tooth structure weak and prone to fracture as is often the case in MPS affected deciduous enamel.
Original languageEnglish
JournalMicron
Early online date12 Jan 2016
DOIs
Publication statusE-pub ahead of print - 12 Jan 2016

Keywords

  • Synchrotron X-ray diffraction
  • Scanning electron microscopy
  • Enamel
  • Mucopolysaccharidosis
  • Preferred orientation
  • Morquio syndrome

Fingerprint

Dive into the research topics of 'Synchrotron X-ray diffraction and scanning electron microscopy to understand enamel affected by metabolic disorder mucopolysaccharidosis'. Together they form a unique fingerprint.

Cite this