Surgery for primary hyperparathyroidism

R. James England*, Hisham Mehanna

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder affecting 0.3 % of the population and up to 1–3 % of postmenopausal women (Jessica et al. 2011). PHPT is diagnosed by a raised serum (corrected) calcium associated with an inappropriately unsuppressed PTH level. It arises from oversecretion of PTH due to parathyroid gland(s) overactivity. Primary HPT may be treated conservatively or surgically. Only approximately one-tenth of diagnosed patients end up undergoing parathyroidectomy. Inherited forms of HPT: Germline mutations leading to loss of heterozygosity in tumor suppressor genes in multiple endocrine neoplasia (MEN)1 and CDC73, combined with a second mutation in somatic cells, can lead to parathyroid tumor development (Jessica et al. 2011).

Original languageEnglish
Title of host publicationTips and tricks in endocrine surgery
PublisherSpringer-Verlag London
Number of pages6
ISBN (Electronic)9781447121466
ISBN (Print)9780857299826
Publication statusPublished - 2014

ASJC Scopus subject areas

  • General Medicine


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