Surgery for Parkinson's disease: lack of reliable clinical trial evidence

R L Stowe, K Wheatley, C E Clarke, N J Ives, R K Hills, Adrian Williams, J P Daniels, R Gray

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


There has been a striking resurgence of interest in surgery for Parkinson's disease (PD) with new targets identified and new procedures developed. This systematic review identified over 500 studies of surgery for PD published since 1990, including over 10 000 patients. However, the authors were unable to assess the value of PD surgery reliably because only seven randomised trials were identified including just 196 patients. Studies of surgery for PD have generally been of poor quality with too few patients, too short follow up, inappropriate choice of outcome measures, and lack of control groups. Much larger, randomised, controlled trials are needed to assess the longer term effects of surgery on patient rated quality of life and cost effectiveness.

Original languageEnglish
Pages (from-to)519-21
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number4
Publication statusPublished - Apr 2003


  • Clinical Trials as Topic
  • Evidence-Based Medicine
  • Humans
  • Outcome Assessment (Health Care)
  • Parkinson Disease
  • Reproducibility of Results
  • Stereotaxic Techniques


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