Supramolecular Photoactivatable Anticancer Hydrogels

V. Venkatesh, Narendra Kumar Mishra, Isolda Romero-canelón, Robbin R. Vernooij, Huayun Shi, James P. C. Coverdale, Abraha Habtemariam, Sandeep Verma, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)
155 Downloads (Pure)

Abstract

A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 μM, blue light) with a photocytotoxic index <2, whereas Pt-G4K+B hydrogels exhibited more potent photocytotoxicity (IC50 3 μM, blue light) with a photocytotoxic index >5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).
Original languageEnglish
Pages (from-to)5656-5659
JournalJournal of the American Chemical Society
Volume139
Issue number16
Early online date17 Apr 2017
DOIs
Publication statusPublished - 26 Apr 2017

Fingerprint

Dive into the research topics of 'Supramolecular Photoactivatable Anticancer Hydrogels'. Together they form a unique fingerprint.

Cite this