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Abstract
The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D models of the structure and dynamics of key regions of the 5' UTR of the SARS-CoV-2 genome. Furthermore, we determine the binding of metallo-supramolecular helicates (cylinders) to this RNA structure. These nano-size agents are uniquely able to thread through RNA junctions and we identify their binding to a 3-base bulge and the central cross 4-way junction located in stem loop 5. Finally, we show these RNA-binding cylinders suppress SARS-CoV-2 replication, highlighting their potential as novel anti-viral agents.
Original language | English |
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Journal | Angewandte Chemie (International Edition) |
Early online date | 29 Apr 2021 |
DOIs | |
Publication status | E-pub ahead of print - 29 Apr 2021 |
Bibliographical note
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.Fingerprint
Dive into the research topics of 'Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*'. Together they form a unique fingerprint.Projects
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Understanding host factors that regulate the hepatitis B viral epigenome
1/10/18 → 31/07/22
Project: Research Councils