Sulfation pathways: Insights into steroid sulfation and desulfation pathways

Paul Foster; Jonathan Wolf Mueller

doi:10.1530/JME-18-0086

Sulfation pathways: Insights into steroid sulfation and desulfation pathways

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

274 Downloads (Pure)

Abstract

Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.

Original language	English
Pages (from-to)	T271–T283
Number of pages	13
Journal	Journal of Molecular Endocrinology
Volume	61
Issue number	2
DOIs	https://doi.org/10.1530/JME-18-0086
Publication status	Published - 1 Aug 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adrenal hormones
androgens
DHEA
hormone action
steroid homones

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10.1530/JME-18-0086Licence: None: All rights reserved

JME-18-0086_accepted_manuscript
Checked for eligibility: 25/05/2018 This is a pre-copyedited, author-produced version of an article accepted for publication in Endocrinology following peer review. The version of record Foster, P.A. and Mueller, J.W., 2018. SULFATION PATHWAYS: Insights into steroid sulfation and desulfation pathways. Journal of molecular endocrinology, 61(2), pp.T271-T283. is available online at: https://doi.org/10.1530/JME-18-0086
Accepted author manuscript, 527 KBLicence: Other (please specify with Rights Statement)

https://jme.bioscientifica.com/view/journals/jme/61/2/JME-18-0086.xmlLicence: None: All rights reserved

Cite this

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title = "Sulfation pathways: Insights into steroid sulfation and desulfation pathways",

abstract = "Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.",

keywords = "adrenal hormones, androgens, DHEA, hormone action, steroid homones",

author = "Paul Foster and Mueller, \{Jonathan Wolf\}",

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language = "English",

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AU - Foster, Paul

AU - Mueller, Jonathan Wolf

PY - 2018/8/1

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N2 - Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.

AB - Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.

KW - adrenal hormones

KW - androgens

KW - DHEA

KW - hormone action

KW - steroid homones

UR - http://europepmc.org/abstract/med/29764919

U2 - 10.1530/JME-18-0086

DO - 10.1530/JME-18-0086

M3 - Review article

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SP - T271–T283

JO - Journal of Molecular Endocrinology

JF - Journal of Molecular Endocrinology

IS - 2

ER -

Sulfation pathways: Insights into steroid sulfation and desulfation pathways

Abstract

UN SDGs

Keywords

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