Sulfasalazine induced seizures and dysphasia

M E Hill, C Gordon, R D Situnayake, D A Heath

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies). Her condition improved spontaneously upon withdrawal of sulfasalazine. Dysphasia has not been reported as a side effect of sulfasalazine.
Original languageEnglish
Pages (from-to)748-9
Number of pages2
JournalThe Journal of Rheumatology
Issue number4
Publication statusPublished - Apr 1994


  • Antibodies, Antineutrophil Cytoplasmic
  • Aphasia
  • Arthritis, Rheumatoid
  • Autoantibodies
  • Female
  • Humans
  • Lupus Erythematosus, Systemic
  • Middle Aged
  • Seizures
  • Sulfasalazine


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